Inhibition of mouse recombinant PARP2 assessed as radioactivity incorporated from [adenine-2,8-3H]NAD into proteins by liquid scintillation spectrometry
Neuroprotective activity in transient middle cerebral artery occlusion Sprague-Dawley rat model assessed as reduction in brain infarct volume at 0.1 mg/kg, ip 3 times, starting 4 hrs after occlusion relative to vehicle treated control
Neuroprotective activity in transient middle cerebral artery occlusion Sprague-Dawley rat model assessed as reduction in brain infarct volume at 1 mg/kg, ip 3 times, starting 4 hrs after occlusion relative to vehicle treated control
Neuroprotective activity in transient middle cerebral artery occlusion Sprague-Dawley rat model assessed as reduction in brain infarct volume at 10 mg/kg, ip 3 times, starting 4 hrs after occlusion relative to vehicle treated control
Neuroprotective activity in permanent middle cerebral artery occlusion Sprague-Dawley rat model assessed as reduction in brain infarct volume at 1 mg/kg, iv 3 times at 30 mins, 3.5 hrs and 6 hrs after occlusion relative to vehicle treated control