| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3223443 | F | Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis | Plasmodium falciparum | 8 | organism-based format | Scientific Literature | ||
| 2. | ALA3223444 | F | Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis | Plasmodium falciparum | 8 | organism-based format | Scientific Literature | ||
| 3. | ALA3223445 | F | Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis | Plasmodium falciparum | 8 | organism-based format | Scientific Literature | ||
| 4. | ALA3223446 | F | Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis | Plasmodium falciparum | 8 | organism-based format | Scientific Literature | ||
| 5. | ALA3223447 | F | Antimalarial activity against schizont stage of atovaquone-resistant Plasmodium falciparum Tm90C2b infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis | Plasmodium falciparum | 8 | organism-based format | Scientific Literature | ||
| 6. | ALA3223448 | F | Antimalarial activity against schizont stage of atovaquone-resistant Plasmodium falciparum Tm90C2b infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis | Plasmodium falciparum | 8 | organism-based format | Scientific Literature | ||
| 7. | ALA3223455 | P | Chemical stability of the compound in aqueous phosphate buffer of pH 7.4 assessed as half life at 100 uM by HPLC analysis | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA3223456 | P | Stability of the compound in RPMI medium assessed as half life at 100 uM by HPLC analysis in presence of 10% human serum | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA3223457 | F | Antitoxoplasma activity against Toxoplasma gondii RH tachyzoites isolated from human brain assessed as parasite growth inhibition after 24 hrs by hematoxylin-eosin staining based light microscopy | Toxoplasma gondii | 5 | organism-based format | Scientific Literature | ||
| 10. | ALA3223458 | F | Antitoxoplasma activity against Toxoplasma gondii RH tachyzoites isolated from human brain assessed as parasite growth inhibition after 48 hrs by hematoxylin-eosin staining based light microscopy | Toxoplasma gondii | 5 | organism-based format | Scientific Literature | ||
| 11. | ALA3223459 | A | Cytotoxicity against rhesus monkey LLC-MK2 cells assessed as cell viability after 48 hrs by MTS assay | Macaca mulatta | 5 | cell-based format | Scientific Literature | ||
| 12. | ALA3223460 | A | Cytotoxicity against concanavalin A stimulated BALB/c mouse splenocytes after 72 hrs by alamar blue dye based plate reader analysis | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 13. | ALA3603064 | F | Antitrypanosomal activity against Trypanosoma brucei gambiense FeoITMAP/1893 assessed as inhibition of parasite growth after 72 hrs by resazurin dye based microplate reader analysis | Trypanosoma brucei gambiense | 7 | organism-based format | Scientific Literature | ||
| 14. | ALA3603065 | A | Cytotoxicity against mouse 3T6 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA3603067 | F | Selectivity index, ratio of CC50 for mouse 3T6 cells to IC50 for Trypanosoma brucei gambiense strain FeoITMAP/1893 | 5 | assay format | Scientific Literature | |||
| 16. | ALA3603147 | F | Antitrypanosomal activity against Trypanosoma brucei brucei CMP infected in Swiss mouse assessed as mean survival time at 100 umol/kg, ip administered as single dose | Trypanosoma brucei brucei | 4 | organism-based format | Scientific Literature | ||
| 17. | ALA3603148 | F | Antitrypanosomal activity against Trypanosoma brucei brucei CMP infected in Swiss mouse assessed as mean survival time at 50 umol/kg, ip administered as single dose | Trypanosoma brucei brucei | 2 | organism-based format | Scientific Literature | ||
| 18. | ALA3603149 | F | Antitrypanosomal activity against Trypanosoma brucei brucei CMP infected in Swiss mouse assessed as cure rate at 100 umol/kg, ip administered as single dose | Trypanosoma brucei brucei | 4 | organism-based format | Scientific Literature | ||
| 19. | ALA3603150 | F | Antitrypanosomal activity against Trypanosoma brucei brucei CMP infected in Swiss mouse assessed as cure rate at 50 umol/kg, ip administered as single dose | Trypanosoma brucei brucei | 2 | organism-based format | Scientific Literature | ||
| 20. | ALA3603151 | T | Toxicity against Swiss mouse infected with Trypanosoma brucei brucei CMP assessed as animal death at 100 umol/kg, ip administered as single dose | Mus musculus | 4 | organism-based format | Scientific Literature |
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