# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3224679 | F | In vivo antibacterial activity against wild type Salmonella typhimurium LT2 assessed as growth inhibition after 20 hrs by microdilution assay | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | ALA3217431 | organism-based format | Scientific Literature | |
2. | ALA3224680 | F | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 30 days by agar microdilution method | Mycobacterium tuberculosis | 20 | ALA3217431 | organism-based format | Scientific Literature | |
3. | ALA3224681 | B | Inhibition of nick joining activity of Mycobacterium tuberculosis full length NAD+-dependent DNA ligase using [gamma32P]ATP-labeled nicked 40 bp DNA as substrate | Mycobacterium tuberculosis | 4 | ALA3217431 | assay format | Scientific Literature | |
4. | ALA3224682 | B | Inhibition of nick joining activity of human DNA ligase 1 using [gamma32P]ATP-labeled nicked 40 bp DNA as substrate | Homo sapiens | 4 | ALA3217431 | single protein format | Scientific Literature | |
5. | ALA3224683 | B | Ratio of IC50 for ATP-dependent bacteriophage T4 DNA ligase to IC50 for Mycobacterium tuberculosis full length NAD+-dependent DNA ligase | 2 | ALA3217431 | assay format | Scientific Literature | ||
6. | ALA3224684 | B | Inhibition of nick joining activity of ATP-dependent bacteriophage T4 DNA ligase using [gamma32P]ATP-labeled nicked 40 bp DNA as substrate | Tequatrovirus T4 | 4 | ALA3217431 | single protein format | Scientific Literature | |
7. | ALA3224685 | B | Ratio of IC50 for human DNA ligase 1 to IC50 for Mycobacterium tuberculosis full length NAD+-dependent DNA ligase | 2 | ALA3217431 | assay format | Scientific Literature | ||
8. | ALA3224686 | F | In vivo antibacterial activity against DNA ligase deficient Salmonella typhimurium variant TT15151 expressing NAD+-dependent T4 DNA ligase gene assessed as growth inhibition after 20 hrs by microdilution assay | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | ALA3217431 | organism-based format | Scientific Literature | |
9. | ALA3223339 | F | In vivo antibacterial activity against Escherichia coli GR501 harboring lig251 temperature-sensitive mutant gene transformed with control plasmid pTrc99A assessed as growth inhibition after 20 hrs by microdilution assay | Escherichia coli | 2 | ALA3217431 | organism-based format | Scientific Literature | |
10. | ALA3223340 | F | In vivo antibacterial activity against Escherichia coli GR501 harboring lig251 temperature-sensitive mutant gene transformed with plasmid encoding Mycobacterium tuberculosis NAD+ DNA ligase assessed as growth inhibition after 20 hrs by microdilution assay | Escherichia coli | 2 | ALA3217431 | organism-based format | Scientific Literature | |
11. | ALA3223341 | F | In vivo antibacterial activity against Escherichia coli GR501 harboring temperature-sensitive lig251 mutant gene transformed with plasmid encoding T4 DNA ligase assessed as growth inhibition after 20 hrs by microdilution assay | Escherichia coli | 2 | ALA3217431 | organism-based format | Scientific Literature | |
12. | ALA3223343 | B | Binding affinity to calf thymus DNA up to 250 uM by ethidium bromide displacement assay | Bos taurus | 2 | ALA3217431 | nucleic acid format | Scientific Literature | |
13. | ALA3223344 | B | Binding affinity to plasmid DNA (unknown origin) by gel electrophoresis mobility shift assay | Not specified | 2 | ALA3217431 | assay format | Scientific Literature |