# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA639388 | P | Solubility | 16 | ALA1136218 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA769865 | F | Effect on IgE/Fcepsilon RI triggered rat basophil cell (RBL-2H3) degranulation assessed by measuring the amount of 5-HT release | 17 | ALA1136218 | assay format | Scientific Literature | ||
3. | ALA808356 | B | Inhibition of human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactis at 80 uM (Inactive) | Homo sapiens | 1 | ALA1136218 | assay format | Scientific Literature | |
4. | ALA2428110 | B | Inhibition of spleen tyrosine kinase (unknown origin) | Homo sapiens | 33 | ALA2424544 | single protein format | Scientific Literature | |
5. | ALA4765708 | B | Inhibition of human MARK3 assessed as residual activity at 0.1 uM relative to control | Homo sapiens | 6 | ALA4765228 | single protein format | Scientific Literature | |
6. | ALA4765709 | B | Inhibition of human MYLK assessed as residual activity at 0.1 uM relative to control | Homo sapiens | 6 | ALA4765228 | single protein format | Scientific Literature | |
7. | ALA4765710 | B | Inhibition of human MST2 assessed as residual activity at 1 uM relative to control | Homo sapiens | 6 | ALA4765228 | single protein format | Scientific Literature | |
8. | ALA4765711 | B | Inhibition of GAL4 fused TrkA (unknown origin) expressed in PC12 cells transfected with pFA2-Elk plasmid and pFR-luciferase plasmid measured for 18 hrs by luciferase reporter gene assay | Homo sapiens | 12 | ALA4765228 | cell-based format | Scientific Literature | |
9. | ALA4765712 | B | Inhibition of GAL4 fused TrkB (unknown origin) expressed in MG87 cells transfected with pFA2-Elk plasmid and pFR-luciferase plasmid measured for 18 hrs by luciferase reporter gene assay | Homo sapiens | 3 | ALA4765228 | cell-based format | Scientific Literature | |
10. | ALA4765713 | B | Inhibition of TrkA (unknown origin) | Homo sapiens | 13 | ALA4765228 | single protein format | Scientific Literature | |
11. | ALA4765714 | B | Inhibition of TrkB (unknown origin) | Homo sapiens | 6 | ALA4765228 | single protein format | Scientific Literature | |
12. | ALA4765715 | B | Inhibition of TrkC (unknown origin) | Homo sapiens | 6 | ALA4765228 | single protein format | Scientific Literature | |
13. | ALA4765716 | B | Inhibition of TrkA phosphorylation in rat PC12 cells at 1 uM after 5 mins in presence of NGF by Western blot analysis | Rattus norvegicus | 3 | ALA4765228 | cell-based format | Scientific Literature | |
14. | ALA4765717 | B | Inhibition of TrkB phosphorylation in mouse MG87 cells transfected with pFA2-Elk plasmid and pFR-luciferase plasmid at 1 uM after 5 mins in presence of BDNF by Western blot analysis | Mus musculus | 3 | ALA4765228 | cell-based format | Scientific Literature | |
15. | ALA4765718 | B | Inhibition of TrkA in rat PC-12 cells assessed as reduction in Akt phosphorylation at 0.01 to 1 uM after 5 mins in presence of NGF by Western blot analysis | Rattus norvegicus | 3 | ALA4765228 | cell-based format | Scientific Literature | |
16. | ALA4765719 | B | Inhibition of TrkB in mouse MG87 cells transfected with pFA2-Elk plasmid and pFR-luciferase plasmid assessed as reduction in Akt phosphorylation at 0.01 to 1 uM after 5 mins in presence of BDNF by Western blot analysis | Mus musculus | 3 | ALA4765228 | cell-based format | Scientific Literature | |
17. | ALA4765720 | B | Inhibition of TrkA in rat PC12 cells assessed as reduction in ERK1/ERK2 phosphorylation at 0.01 to 1 uM after 5 mins in presence of NGF by Western blot analysis | Rattus norvegicus | 3 | ALA4765228 | cell-based format | Scientific Literature | |
18. | ALA4765721 | B | Inhibition of TrkB in mouse MG87 cells transfected with pFA2-Elk plasmid and pFR-luciferase plasmid assessed as reduction in ERK1/ERK2 phosphorylation at 0.01 to 1 uM after 5 mins in presence of BDNF by Western blot analysis | Mus musculus | 3 | ALA4765228 | cell-based format | Scientific Literature | |
19. | ALA4765722 | P | Aqueous solubility of the compound in methanol incubated for 60 min by RP-HPLC-DAD analysis | 3 | ALA4765228 | small-molecule physicochemical format | Scientific Literature | ||
20. | ALA4765723 | A | Cytotoxicity against Wistar rat cortical neuron assessed as neuron survival at 0.01 to 1 uM incubated for 24 hrs | Rattus norvegicus | 3 | ALA4765228 | cell-based format | Scientific Literature |