| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3243357 | B | Inhibition of RRM1 in human U2OS cells assessed as gammaH2AX induction after 2 hrs by FITC/propidium iodide-staining based flow cytometry in presence of SCH900776 | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA3243358 | B | Binding affinity to yeast RRM1 assessed as reduction of unbound compound level by line-broadening NMR spectroscopy | Saccharomyces cerevisiae | 1 | assay format | Scientific Literature | ||
| 3. | ALA3243390 | B | Inhibition of RRM1 in human U2OS cells assessed as gammaH2AX induction at 0.5 to 125 uM after 2 hrs by FITC/propidium iodide-staining based flow cytometry in presence of SCH900776 | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 4. | ALA3243391 | B | Binding affinity to yeast RRM1 assessed as reduction of free compound level by line-broadening NMR spectroscopy relative to control | Saccharomyces cerevisiae | 1 | assay format | Scientific Literature | ||
| 5. | ALA3243392 | B | Binding affinity to yeast RRM1 assessed as reduction of unbound-compound level at 200 uM by NOESY-spectroscopy | Saccharomyces cerevisiae | 1 | assay format | Scientific Literature | ||
| 6. | ALA3243393 | B | Competitive binding affinity to yeast RRM1 assessed as reduction in CDP NMR signals by STD-NMR spectroscopy | Saccharomyces cerevisiae | 1 | assay format | Scientific Literature | ||
| 7. | ALA3243394 | B | Inhibition of RRM1 in human U2OS cells assessed as gammaH2AX induction at 0.5 to 125 uM after 2 hrs by FITC/propidium iodide-staining based flow cytometry in absence of SCH900776 | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA3243395 | B | Inhibition of human RRM1/RNR2 activity using CDP as substrate assessed as reduction of dCDP production at 100 uM preincubated for 30 mins followed by substrate addition measured after 1 hr by NMR spectroscopy | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 9. | ALA3243396 | B | Inhibition of RRM1 in human CEM cells assessed as depletion of dATP level at 1 uM after 2 hrs by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA3243397 | B | Inhibition of human RRM1/RNR2 activity using CDP as substrate assessed as reduction of CDP consumption at 100 uM preincubated for 30 mins followed by substrate addition measured after 1 hr by NMR spectroscopy | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 11. | ALA3243398 | B | Inhibition of RRM1 in human CEM cells assessed as depletion of dCTP level at 1 uM after 2 hrs by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA3243399 | B | Inhibition of RRM1 in human CEM cells assessed as depletion of dGTP level at 1 uM after 2 hrs by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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