# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3242256 | Binding | Displacement of FITC-geldanamycin from recombinant HSP90alpha (unknown origin) after 2 hrs by fluorescence polarization assay | Homo sapiens | 38 | ALA3232825 | single protein format | Scientific Literature | |
2. | ALA3242257 | Binding | Displacement of FITC-geldanamycin from recombinant HSP90beta (unknown origin) after 2 hrs by fluorescence polarization assay | Homo sapiens | 38 | ALA3232825 | single protein format | Scientific Literature | |
3. | ALA3242258 | Binding | Displacement of FITC-geldanamycin from recombinant GRP94 (unknown origin) after 2 hrs by fluorescence polarization assay | Homo sapiens | 37 | ALA3232825 | single protein format | Scientific Literature | |
4. | ALA3242259 | Binding | Displacement of FITC-geldanamycin from recombinant TRAP1 (unknown origin) after 2 hrs by fluorescence polarization assay | Homo sapiens | 37 | ALA3232825 | single protein format | Scientific Literature | |
5. | ALA3242260 | Binding | Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysis | Homo sapiens | 31 | ALA3232825 | cell-based format | Scientific Literature | |
6. | ALA3242261 | Binding | Inhibition of HSP90 in Huntington's disease patient derived fibroblasts assessed as reduction of mHtt level after 48 hrs by Western blot analysis | Homo sapiens | 4 | ALA3232825 | single protein format | Scientific Literature | |
7. | ALA3242265 | ADME | AUC in Sprague-Dawley rat plasma at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA3232825 | organism-based format | Scientific Literature | |
8. | ALA3242267 | ADME | Clearance in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA3232825 | organism-based format | Scientific Literature | |
9. | ALA3242268 | ADME | Volume of distribution in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA3232825 | organism-based format | Scientific Literature | |
10. | ALA3242269 | ADME | Half life in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA3232825 | organism-based format | Scientific Literature | |
11. | ALA3242274 | Binding | Binding affinity to recombinant HSP90alpha (unknown origin) at 10 uM by isothermal calorimetry assay | Homo sapiens | 2 | ALA3232825 | single protein format | Scientific Literature | |
12. | ALA3242277 | Unassigned | Ratio of CC50 for Huntington's disease patient derived fibroblasts to IC50 for HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level | Homo sapiens | 2 | ALA3232825 | cell-based format | Scientific Literature | |
13. | ALA3242278 | ADME | Cytotoxicity against Huntington's disease patient derived fibroblasts after 48 hrs by CellTiter Glo assay | Homo sapiens | 3 | ALA3232825 | cell-based format | Scientific Literature | |
14. | ALA3242279 | ADME | AUC in Sprague-Dawley rat plasma at 5 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3232825 | organism-based format | Scientific Literature | |
15. | ALA3242280 | ADME | Half life in Sprague-Dawley rat at 5 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3232825 | organism-based format | Scientific Literature | |
16. | ALA3242281 | ADME | Ratio of drug level in brain to plasma in Sprague-Dawley rat at 5 mg/kg, po after 6 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3232825 | organism-based format | Scientific Literature | |
17. | ALA3242282 | ADME | Oral bioavailability in Sprague-Dawley rat at 5 mg/kg by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3232825 | organism-based format | Scientific Literature | |
18. | ALA3242283 | Functional | Reduction of mHtt level in Sprague-Dawley rat brain at 5 mg/kg, po qd for 1 week | Rattus norvegicus | 1 | ALA3232825 | organism-based format | Scientific Literature | |
19. | ALA3242284 | Toxicity | Toxicity in Sprague-Dawley rat brain at 5 mg/kg, po qd for 1 week | Rattus norvegicus | 1 | ALA3232825 | organism-based format | Scientific Literature | |
20. | ALA4713206 | Binding | Inhibition of FITC-GDA binding to human HSP90-beta incubated for 2 hrs by fluorescence polarization assay | Homo sapiens | 22 | ALA4706657 | single protein format | Scientific Literature |