| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3242256 | B | Displacement of FITC-geldanamycin from recombinant HSP90alpha (unknown origin) after 2 hrs by fluorescence polarization assay | Homo sapiens | 38 | single protein format | Scientific Literature | ||
| 2. | ALA3242257 | B | Displacement of FITC-geldanamycin from recombinant HSP90beta (unknown origin) after 2 hrs by fluorescence polarization assay | Homo sapiens | 38 | single protein format | Scientific Literature | ||
| 3. | ALA3242258 | B | Displacement of FITC-geldanamycin from recombinant GRP94 (unknown origin) after 2 hrs by fluorescence polarization assay | Homo sapiens | 37 | single protein format | Scientific Literature | ||
| 4. | ALA3242259 | B | Displacement of FITC-geldanamycin from recombinant TRAP1 (unknown origin) after 2 hrs by fluorescence polarization assay | Homo sapiens | 37 | single protein format | Scientific Literature | ||
| 5. | ALA3242260 | B | Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysis | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 6. | ALA3242261 | B | Inhibition of HSP90 in Huntington's disease patient derived fibroblasts assessed as reduction of mHtt level after 48 hrs by Western blot analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 7. | ALA3242265 | A | AUC in Sprague-Dawley rat plasma at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 8. | ALA3242267 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 9. | ALA3242268 | A | Volume of distribution in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 10. | ALA3242269 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 11. | ALA3242274 | B | Binding affinity to recombinant HSP90alpha (unknown origin) at 10 uM by isothermal calorimetry assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 12. | ALA3242277 | U | Ratio of CC50 for Huntington's disease patient derived fibroblasts to IC50 for HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA3242278 | A | Cytotoxicity against Huntington's disease patient derived fibroblasts after 48 hrs by CellTiter Glo assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA3242279 | A | AUC in Sprague-Dawley rat plasma at 5 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA3242280 | A | Half life in Sprague-Dawley rat at 5 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3242281 | A | Ratio of drug level in brain to plasma in Sprague-Dawley rat at 5 mg/kg, po after 6 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3242282 | A | Oral bioavailability in Sprague-Dawley rat at 5 mg/kg by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3242283 | F | Reduction of mHtt level in Sprague-Dawley rat brain at 5 mg/kg, po qd for 1 week | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3242284 | T | Toxicity in Sprague-Dawley rat brain at 5 mg/kg, po qd for 1 week | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4713206 | B | Inhibition of FITC-GDA binding to human HSP90-beta incubated for 2 hrs by fluorescence polarization assay | Homo sapiens | 22 | single protein format | Scientific Literature |
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