# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3243737 | B | Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate preincubated for 10 mins measured after 30 mins by spectrophotometer analysis | Homo sapiens | 8 | ALA3232818 | single protein format | Scientific Literature | |
2. | ALA3243740 | B | Inhibition of human recombinant IDE-mediated amyloid beta (1 to 40) hydrolysis preincubated for 10 mins measured after 30 mins by spectrophotometer analysis | Homo sapiens | 1 | ALA3232818 | single protein format | Scientific Literature | |
3. | ALA3243742 | B | Induction of human recombinant IDE-mediated insulin hydrolysis preincubated for 10 mins measured after 30 mins by spectrophotometer analysis | Homo sapiens | 1 | ALA3232818 | single protein format | Scientific Literature | |
4. | ALA3243743 | B | Induction of human recombinant IDE-mediated IGF-2 hydrolysis preincubated for 10 mins measured after 30 mins by spectrophotometer analysis | Homo sapiens | 1 | ALA3232818 | single protein format | Scientific Literature | |
5. | ALA3243744 | B | Inhibition of human recombinant IDE-mediated somatostatin hydrolysis preincubated for 10 mins measured after 30 mins by spectrophotometer analysis | Homo sapiens | 1 | ALA3232818 | single protein format | Scientific Literature | |
6. | ALA3243745 | B | Inhibition of human recombinant IDE-mediated glucagon hydrolysis preincubated for 10 mins measured after 30 mins by spectrophotometer analysis | Homo sapiens | 1 | ALA3232818 | single protein format | Scientific Literature | |
7. | ALA3243746 | B | Inhibition of human NEP-mediated amyloid beta hydrolysis | Homo sapiens | 2 | ALA3232818 | single protein format | Scientific Literature | |
8. | ALA3243747 | B | Inhibition of human recombinant ECE1-mediated amyloid beta hydrolysis after 45 mins by fluorimetry assay | Homo sapiens | 1 | ALA3232818 | single protein format | Scientific Literature | |
9. | ALA3243748 | B | Inhibition of human ACE-mediated amyloid beta hydrolysis | Homo sapiens | 2 | ALA3232818 | single protein format | Scientific Literature | |
10. | ALA3243749 | B | Inhibition of human recombinant ACE2-mediated amyloid beta hydrolysis using Mca-Tyr-Val-Ala-Asp-Pro-Ala-Lys-(DNP)-OH as substrate after 20 mins by fluorimetry assay | Homo sapiens | 1 | ALA3232818 | single protein format | Scientific Literature | |
11. | ALA3243750 | B | Inhibition of human recombinant TACE-mediated amyloid beta hydrolysis after 5 mins by fluorimetry assay | Homo sapiens | 1 | ALA3232818 | single protein format | Scientific Literature | |
12. | ALA3243751 | B | Inhibition of human recombinant MMP1-mediated amyloid beta hydrolysis using DNP-Pro-Cha-Gly- Cys(Me)-His-Ala- Lys(n-Me-Abz)-NH2 as substrate after 40 mins by fluorimetry assay | Homo sapiens | 1 | ALA3232818 | single protein format | Scientific Literature | |
13. | ALA3243752 | B | Inhibition of human recombinant MMP13-mediated amyloid beta hydrolysis after 10 mins by fluorimetry assay | Homo sapiens | 1 | ALA3232818 | single protein format | Scientific Literature | |
14. | ALA3243754 | P | Solubility of the compound in PBS at pH 7.4 | 2 | ALA3232818 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA3243755 | P | PBS-octanol partition coefficient, log D of the compound | 2 | ALA3232818 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA3243759 | A | Half life in mouse plasma at 10 uM by LC-MS/MS analysis | Mus musculus | 1 | ALA3232818 | cell-free format | Scientific Literature | |
17. | ALA3243760 | A | Half life in human liver microsomes at 1 uM by LC-MS/MS analysis | Homo sapiens | 1 | ALA3232818 | assay format | Scientific Literature | |
18. | ALA3243761 | P | Half life in IHH cell culture medium at 10 uM by LC-MS/MS analysis | 1 | ALA3232818 | small-molecule physicochemical format | Scientific Literature | ||
19. | ALA4399074 | B | Inhibition of IDE exosite and catalytic site (unknown origin) | Homo sapiens | 1 | ALA4396912 | single protein format | Scientific Literature |