| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3239890 | B | Inhibition of IDE in human SH-SY5Y cells expressing human APP751 with Swedish mutant/human APP696 assessed as increase of amyloid beta (1 to 42) level after 24 to 48 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA3239891 | B | Inhibition of IDE in human SH-SY5Y cells expressing human APP751 with Swedish mutant/human APP696 assessed as effect on APP holoproteins level after 24 to 48 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA3239892 | B | Inhibition of IDE in human SH-SY5Y cells expressing human APP751 with Swedish mutant/human APP696 assessed as effect on CTFs level after 24 to 48 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA3239893 | B | Inhibition of IDE in mouse Min6 cells assessed as effect on 2.8 mM of glucose-induced insulin secretion at 10 uM after 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA3239894 | B | Inhibition of IDE in mouse Min6 cells assessed as effect on 11 mM of glucose-induced insulin secretion at 10 uM after 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3239895 | B | Inhibition of IDE in mouse Min6 cells assessed as effect on 20 mM of glucose-induced insulin secretion at 10 uM after 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA3239896 | B | Inhibition of IDE in immortalized human hepatocytes assessed as effect on insulin-induced PEPCK mRNA expression at 10 uM after 24 hrs by quantitative RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA3243737 | B | Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate preincubated for 10 mins measured after 30 mins by spectrophotometer analysis | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 9. | ALA3243753 | B | Inhibition of human recombinant IDE-mediated insulin hydrolysis assessed as residual insulin level at 100 uM preincubated for 10 mins measured after 30 mins by spectrophotometer analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA3243754 | P | Solubility of the compound in PBS at pH 7.4 | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 11. | ALA3243755 | P | PBS-octanol partition coefficient, log D of the compound | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA3243756 | A | Apparent permeability across human Caco2 cells at 10 uM after 1 hr by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA3243757 | A | Prodrug conversion in mouse plasma assessed as half life of BDM43079 formation at 10 uM by LC-MS/MS analysis | Mus musculus | 1 | cell-free format | Scientific Literature | ||
| 14. | ALA3243758 | A | Prodrug conversion in IHH cell culture medium assessed as half life of BDM43079 formation at 10 uM by LC-MS/MS analysis | 1 | cell-based format | Scientific Literature | |||
| 15. | ALA3243762 | B | Inhibition of IDE in human SH-SY5Y cells expressing human APP751 with Swedish mutant/human APP696 assessed as increase of amyloid beta (1 to 40) level after 24 to 48 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature |
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