| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3241055 | P | Prodrug activation assessed as GSH reactivity in aqueous phosphate buffer at pH 7.4 by UV-Visible spectrophotometer analysis | 5 | ALA3232734 | small-molecule physicochemical format | Scientific Literature | ||
| 2. | ALA3242908 | A | Ratio of prodrug activation in presence of GSH and recombinant GSTP1 (unknown origin) to prodrug activation in presence of GSH by UV-Visible spectrophotometry | Homo sapiens | 4 | ALA3232734 | single protein format | Scientific Literature | |
| 3. | ALA3242909 | A | Ratio of prodrug activation in presence of GSH and recombinant GSTA1 (unknown origin) to prodrug activation in presence of GSH by UV-Visible spectrophotometry | Homo sapiens | 4 | ALA3232734 | single protein format | Scientific Literature | |
| 4. | ALA3242910 | B | Inhibition of PARP-1 (unknown origin) assessed as incorporation of biotinylated poly ADP-ribose onto histone proteins at 0.1 to 1000 nM by colorimetric analysis in presence of GSH and GSTP1 | Homo sapiens | 1 | ALA3232734 | single protein format | Scientific Literature | |
| 5. | ALA3242911 | A | Drug metabolism in human A549 cells assessed as nitric oxide release at 10 uM by LC/MS/MS analysis in presence of GSH/GSTP1 | Homo sapiens | 1 | ALA3232734 | cell-based format | Scientific Literature | |
| 6. | ALA3242912 | A | Drug metabolism in human U937 cells assessed as nitric oxide release at 10 uM by LC/MS/MS analysis in presence of GSH/GSTP1 | Homo sapiens | 1 | ALA3232734 | cell-based format | Scientific Literature | |
| 7. | ALA3242913 | F | Induction of endoplasmic reticulum stress in human A549 cells assessed as protein glutathionylation measured within 1 hr post-drug treatment by immunoblot analysis | Homo sapiens | 1 | ALA3232734 | cell-based format | Scientific Literature | |
| 8. | ALA3242914 | F | Induction of endoplasmic reticulum stress in human A549 cells assessed as protein glutathionylation after 8 hrs by immunoblot analysis | Homo sapiens | 1 | ALA3232734 | cell-based format | Scientific Literature | |
| 9. | ALA3242915 | F | Induction of apoptosis in human A549 cells assessed as cleaved PARP level after 8 hrs by immunoblot analysis | Homo sapiens | 1 | ALA3232734 | cell-based format | Scientific Literature | |
| 10. | ALA3242916 | B | Induction of eIF2-alpha phosphorylation in human A549 cells by immunoblot analysis | Homo sapiens | 1 | ALA3232734 | cell-based format | Scientific Literature | |
| 11. | ALA3242917 | F | Induction of endoplasmic reticulum stress in human A549 cells assessed as upregulation of CHOP protein expression by immunoblot analysis | Homo sapiens | 1 | ALA3232734 | cell-based format | Scientific Literature | |
| 12. | ALA3242918 | F | Induction of endoplasmic reticulum stress in human A549 cells assessed as upregulation of BiP protein expression by immunoblot analysis | Homo sapiens | 1 | ALA3232734 | cell-based format | Scientific Literature | |
| 13. | ALA3240062 | F | Induction of endoplasmic reticulum stress in human A549 cells assessed as upregulation of ATF4 protein expression by immunoblot analysis | Homo sapiens | 1 | ALA3232734 | cell-based format | Scientific Literature | |
| 14. | ALA3240063 | B | Induction of p38 phosphorylation in human A549 cells within 15 mins after drug treatment by immunoblot analysis | Homo sapiens | 1 | ALA3232734 | cell-based format | Scientific Literature | |
| 15. | ALA3240064 | B | Induction of p38 phosphorylation in human A549 cells after 8 hrs by immunoblot analysis | Homo sapiens | 1 | ALA3232734 | cell-based format | Scientific Literature | |
| 16. | ALA3240065 | F | Induction of apoptosis in human A549 cells assessed as cleaved caspase 8 level at 1 uM within 6 hrs after drug treatment by immunoblot analysis | Homo sapiens | 1 | ALA3232734 | cell-based format | Scientific Literature | |
| 17. | ALA3240066 | F | Induction of apoptosis in human A549 cells assessed as cleaved caspase 3 level by immunoblot analysis | Homo sapiens | 1 | ALA3232734 | cell-based format | Scientific Literature | |
| 18. | ALA3240067 | F | Induction of apoptosis in human A549 cells assessed as cleaved caspase 7 level by immunoblot analysis | Homo sapiens | 1 | ALA3232734 | cell-based format | Scientific Literature | |
| 19. | ALA3240068 | F | Induction of apoptosis in human A549 cells assessed as cleaved PARP level by immunoblot analysis | Homo sapiens | 1 | ALA3232734 | cell-based format | Scientific Literature | |
| 20. | ALA3240069 | F | Anticancer activity against human A549 cells xenografted in NCr nu/nu athymic mouse assessed as reduction of tumor growth at 92 umol/kg, iv administered two times a week for 4 weeks | Homo sapiens | 2 | ALA3232734 | organism-based format | Scientific Literature |
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