Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 0.25 mg/kg, po after 0 to 30 mins dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 0.25 mg/kg, po after 30 to 60 mins dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 0.25 mg/kg, po after 60 to 90 mins dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 0.50 mg/kg, po after 90 to 120 mins dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 0.50 mg/kg, po after 120 to 150 mins dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 0.50 mg/kg, po after 150 to 180 mins dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 1 mg/kg, po after 180 to 210 mins dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 1 mg/kg, po after 210 to 240 mins dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 1 mg/kg, po after 240 to 270 mins dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 1 mg/kg, po 6 days later animal received test compound followed by 0.75 mg/kg, im benztropine 15 mins later measured after 0 to 0.5 hrs of dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 1 mg/kg, po 6 days later animal received test compound followed by 0.75 mg/kg, im benztropine 15 mins later measured after 0.5 to 1 hrs of dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 1 mg/kg, po 6 days later animal received test compound followed by 0.75 mg/kg, im benztropine 15 mins later measured after 1 to 1.5 hrs of dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 1 mg/kg, po 6 days later animal received test compound followed by 0.75 mg/kg, im benztropine 15 mins later measured after 1.5 to 2 hrs of dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 1 mg/kg, po 6 days later animal received test compound followed by 0.75 mg/kg, im benztropine 15 mins later measured after 2 to 2.5 hrs of dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 1 mg/kg, po 6 days later animal received test compound followed by 0.75 mg/kg, im benztropine 15 mins later measured after 2.5 to 3 hrs of dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 1 mg/kg, po 6 days later animal received test compound followed by 0.75 mg/kg, im benztropine 15 mins later measured after 3 to 3.5 hrs of dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 1 mg/kg, po 6 days later animal received test compound followed by 0.75 mg/kg, im benztropine 15 mins later measured after 3.5 to 4 hrs of dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 1 mg/kg, po 6 days later animal received test compound followed by 0.75 mg/kg, im benztropine 15 mins later measured after 4 to 4.5 hrs of dosing
Antipsychotic activity in squirrel monkey assessed as inhibition of conditioned avoidance response measured as maximum number of shocks possible per 30 mins interval at 1 mg/kg, po 10 days later animal received test compound and again saline measured after 0 to 0.5 hrs of dosing