Antiviral activity against Vaccinia virus infected in human KB cells assessed as inhibition of virus-induced cytopathic effect at 1 to 1000 ug/ml after 72 hrs
Antiviral activity against Parainfluenza virus type 3 infected in human KB cells assessed as inhibition of virus-induced cytopathic effect at 1 to 1000 ug/ml after 72 hrs
Antiviral activity against Rhinovirus type 13 infected in human KB cells assessed as inhibition of virus-induced cytopathic effect at 1 to 1000 ug/ml after 72 hrs
Antiviral activity against Adenovirus type 3 infected in human KB cells assessed as inhibition of virus-induced cytopathic effect at 1 to 1000 ug/ml after 72 hrs
Toxicity in Swiss mouse infected with Influenza A2 virus Japan 305 assessed as survival at 75 mg/kg/day, po bid administered for 9 days started at 4 hrs prior to infection
Toxicity in Swiss mouse infected with Influenza B virus Lee assessed as survival at 75 mg/kg/day, ip bid administered for 9 days started at 4 hrs prior to infection
Toxicity in Swiss mouse infected with Murine hepatitis virus Friend-Braunsteiner assessed as survival at 75 mg/kg/day, ip bid administered for 8 days started at 2 hrs prior to infection
Toxicity in Swiss mouse infected with Murine hepatitis virus Friend-Braunsteiner assessed as survival at 37.5 mg/kg/day, ip bid administered for 8 days started at 2 hrs prior to infection
Toxicity in Swiss mouse infected with Murine hepatitis virus Friend-Braunsteiner assessed as survival at 18.8 mg/kg/day, ip bid administered for 8 days started at 2 hrs prior to infection
Antiviral activity against Influenza A2 virus Japan 305 infected in Swiss mouse assessed as survival at 75 mg/kg/day, po bid administered for 9 days relative to control
Antiviral activity against Influenza B virus Lee infected in Swiss mouse assessed as survival at 75 mg/kg/day, ip bid administered for 9 days relative to control
Antiviral activity against Murine hepatitis virus Friend-Braunsteiner infected in Swiss mouse assessed as survival at 18.8 to 75 mg/kg/day, ip bid administered for 8 days relative to control
Antiviral activity against Influenza A2 virus Japan 305 infected in Swiss mouse assessed as mean survival time at 75 mg/kg/day, po bid administered for 9 days (Rvb = 9 days)
Antiviral activity against Influenza B virus Lee infected in Swiss mouse assessed as mean survival time at 75 mg/kg/day, ip bid administered for 9 days (Rvb = 11.2 days)
Antiviral activity against Murine hepatitis virus Friend-Braunsteiner infected in Swiss mouse assessed as mean survival time at 75 mg/kg/day, ip bid administered for 8 days (Rvb = 5.2 days)
Antiviral activity against Murine hepatitis virus Friend-Braunsteiner infected in Swiss mouse assessed as mean survival time at 37.5 mg/kg/day, ip bid administered for 8 days (Rvb = 5.2 days)
Antiviral activity against Murine hepatitis virus Friend-Braunsteiner infected in Swiss mouse assessed as mean survival time at 18.8 mg/kg/day, ip bid administered for 8 days (Rvb = 5.2 days)
Antiviral activity against Murine hepatitis virus Friend-Braunsteiner infected in ip dosed Swiss mouse assessed as most effective dose administered bid for 8 days