# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3271170 | A | Cytotoxicity against polyamine transporter deficient CHO-MG cells assessed as cell growth after 48 hrs incubation by MTS assay in presence of 1 mM aminoguanidine | Cricetulus griseus | 6 | ALA3259541 | cell-based format | Scientific Literature | |
2. | ALA3271171 | A | Cytotoxicity against CHO cells assessed as cell growth after 48 hrs incubation by MTS assay in presence of 1 mM aminoguanidine | Cricetulus griseus | 6 | ALA3259541 | cell-based format | Scientific Literature | |
3. | ALA3271172 | A | Selectivity ratio of IC50 for polyamine transporter deficient CHO-MG cells to IC50 for CHO cells by MTS assay | Cricetulus griseus | 6 | ALA3259541 | cell-based format | Scientific Literature | |
4. | ALA3271174 | F | Cytotoxicity against human L3.6PL cells assessed as inhibition of cell growth after 48 hrs incubation by MTS assay in presence of 250 uM aminoguanidine treated 24 hrs prior compound addition | Homo sapiens | 6 | ALA3259541 | cell-based format | Scientific Literature | |
5. | ALA3271175 | F | Antimigratory activity against human L3.6PL cells assessed as cell migration inhibition after 48 hrs incubation by wound healing assay in presence of 250 uM aminoguanidine treated 24 hrs prior compound addition | Homo sapiens | 2 | ALA3259541 | cell-based format | Scientific Literature | |
6. | ALA3266852 | F | Antimigratory activity against human L3.6PL cells assessed as cell migration inhibition at 0.6 uM after 48 hrs incubation by wound healing assay in presence of 250 uM aminoguanidine treated 24 hrs prior compound addition | Homo sapiens | 6 | ALA3259541 | cell-based format | Scientific Literature | |
7. | ALA3266855 | F | Antimigratory activity against human L3.6PL cells assessed as cell migration inhibition at 80 uM after 48 hrs incubation by wound healing assay in presence of 250 uM aminoguanidine treated 24 hrs prior compound addition | Homo sapiens | 1 | ALA3259541 | cell-based format | Scientific Literature | |
8. | ALA3266859 | T | Toxicity in immune-compromised mouse assessed as adverse event at 2.66 mg/kg,ip 5 days per week for 2 weeks | Mus musculus | 1 | ALA3259541 | organism-based format | Scientific Literature | |
9. | ALA3267174 | F | Antimetastatic activity against human L3.6PL cells injected into pancreas of immune-compromised mouse assessed as liver micrometastasis at 2.66 mg/kg,ip 5 days per week for 2 weeks after 7 days of tumor cells inoculation by microscopically | Homo sapiens | 1 | ALA3259541 | organism-based format | Scientific Literature | |
10. | ALA3267175 | F | Antimetastatic activity against human L3.6PL cells injected into pancreas of immune-compromised mouse assessed as liver micrometastasis at 2.5 mg/kg,ip 5 days per week for 2 weeks after 7 days of tumor cells inoculation by Hematoxylin and eosin staining | Homo sapiens | 1 | ALA3259541 | organism-based format | Scientific Literature | |
11. | ALA3267177 | F | Antimetastatic activity against human L3.6PL cells injected into pancreas of immune-compromised mouse assessed as liver micrometastasis at 2.5 mg/kg,ip 5 days per week for 2 weeks after 7 days of tumor cells inoculation by human Ki67 immunohistochemical staining | Homo sapiens | 1 | ALA3259541 | organism-based format | Scientific Literature | |
12. | ALA3267179 | F | Effect on intracellular ceramide population in human L3.6PL cells assessed as sphingomyelin N16:0 level measured as contribution to total ceramide population at 0.6 uM after 48 hrs incubation by mass spectrometry analysis (Rvb = 37.3%) | Homo sapiens | 2 | ALA3259541 | cell-based format | Scientific Literature | |
13. | ALA3267180 | F | Effect on intracellular ceramide population in human L3.6PL cells assessed as sphingomyelin N22:1 level measured as contribution to total ceramide population at 0.6 uM after 48 hrs incubation by mass spectrometry analysis (Rvb = 6.5%) | Homo sapiens | 2 | ALA3259541 | cell-based format | Scientific Literature | |
14. | ALA3267181 | F | Effect on intracellular ceramide population in human L3.6PL cells assessed as sphingomyelin N20:0 level measured as contribution to total ceramide population at 0.6 uM after 48 hrs incubation by mass spectrometry analysis (Rvb = 1.1%) | Homo sapiens | 2 | ALA3259541 | cell-based format | Scientific Literature | |
15. | ALA3267182 | F | Effect on intracellular ceramide population in human L3.6PL cells assessed as sphingomyelin N14:0 level measured per mg of protein at 0.6 uM after 48 hrs incubation by mass spectrometry analysis (Rvb = 0.12 +/- 0.03 nmol) | Homo sapiens | 2 | ALA3259541 | cell-based format | Scientific Literature | |
16. | ALA3267183 | F | Effect on intracellular ceramide population in human L3.6PL cells assessed as sphingomyelin N15:0 level measured per mg of protein at 0.6 uM after 48 hrs incubation by mass spectrometry analysis (Rvb = 0.09 +/- 0.02 nmol) | Homo sapiens | 2 | ALA3259541 | cell-based format | Scientific Literature | |
17. | ALA3267184 | F | Effect on intracellular ceramide population in human L3.6PL cells assessed as sphingomyelin N16:1 level measured per mg of protein at 0.6 uM after 48 hrs incubation by mass spectrometry analysis (Rvb = 0.24 +/- 0.04 nmol) | Homo sapiens | 2 | ALA3259541 | cell-based format | Scientific Literature | |
18. | ALA3267185 | F | Effect on intracellular ceramide population in human L3.6PL cells assessed as sphingomyelin N16:0 level measured per mg of protein at 0.6 uM after 48 hrs incubation by mass spectrometry analysis (Rvb = 3.21 +/- 0.90 nmol) | Homo sapiens | 2 | ALA3259541 | cell-based format | Scientific Literature | |
19. | ALA3267186 | F | Effect on intracellular ceramide population in human L3.6PL cells assessed as sphingomyelin N17:0 level measured per mg of protein at 0.6 uM after 48 hrs incubation by mass spectrometry analysis (Rvb = 0.09 +/- 0.03 nmol) | Homo sapiens | 2 | ALA3259541 | cell-based format | Scientific Literature | |
20. | ALA3267187 | F | Effect on intracellular ceramide population in human L3.6PL cells assessed as sphingomyelin N18:1 level measured per mg of protein at 0.6 uM after 48 hrs incubation by mass spectrometry analysis (Rvb = 0.08 +/- 0.02 nmol) | Homo sapiens | 2 | ALA3259541 | cell-based format | Scientific Literature |