# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3269471 | F | Antifilarial activity against Brugia malayi adult worm infected in jird assessed as microfilaricidal activity at 100 mg/kg, sc administered for 5 days starting from day 7/8 post-worm transplantation measured on day 7 post-initiation of drug treatment | Brugia malayi | 1 | organism-based format | Scientific Literature | ||
2. | ALA3269472 | F | Antifilarial activity against Brugia malayi adult worm assessed as inhibition of parasite motility after 48 hrs by microscopic analysis | Brugia malayi | 16 | organism-based format | Scientific Literature | ||
3. | ALA3269473 | F | Antifilarial activity against Brugia malayi adult worm assessed as inhibition of parasite viability after 48 hrs by MTT assay | Brugia malayi | 14 | organism-based format | Scientific Literature | ||
4. | ALA3269474 | A | Cytotoxicity against African green monkey Vero C1008 cells assessed as cell death by three-fold serial dilution method | Chlorocebus sabaeus | 5 | cell-based format | Scientific Literature | ||
5. | ALA3269475 | F | Selectivity index, ratio of CC50 for African green monkey Vero C1008 cells to IC50 for Brugia malayi adult worm | 4 | cell-based format | Scientific Literature | |||
6. | ALA3269476 | F | Antifilarial activity against Brugia malayi microflilariae worm assessed as inhibition of parasite motility after 48 hrs by microscopic analysis | Brugia malayi | 16 | organism-based format | Scientific Literature | ||
7. | ALA3269477 | F | Selectivity index, ratio of CC50 for African green monkey Vero C1008 cells to IC50 for Brugia malayi microflilariae worm | 5 | cell-based format | Scientific Literature | |||
8. | ALA3269478 | F | Antifilarial activity against Brugia malayi adult worm infected in jird assessed as embryostatic effect at 100 mg/kg, sc administered for 5 days starting from day 7/8 post-worm transplantation (Rvb = 9.80 +/- 5.63%) | Brugia malayi | 2 | organism-based format | Scientific Literature | ||
9. | ALA3269479 | F | Antifilarial activity against Brugia malayi adult worm infected in jird assessed as macrofilaricidal efficacy by measuring reduction in adult worm recovery at 100 mg/kg, sc administered for 5 days starting from day 7/8 post-worm transplantation measured on day 60 post-initiation of drug treatment | Brugia malayi | 1 | organism-based format | Scientific Literature | ||
10. | ALA3269484 | T | Toxicity in jird infected with Brugia malayi adult worm assessed as normal behaviour at 100 mg/kg, sc administered for 5 days starting from day 7/8 post-worm transplantation measured on day 60 post-initiation of drug treatment | Meriones unguiculatus | 2 | organism-based format | Scientific Literature | ||
11. | ALA3269485 | F | Antifilarial activity against third stage infective larvae (L3) form of Brugia malayi infected in Mastomys coucha assessed as reduction in adult worm recovery at 100 mg/kg, sc administered for 5 days measured on day 91 post-initiation of drug treatment | Brugia malayi | 2 | organism-based format | Scientific Literature | ||
12. | ALA3269486 | F | Antifilarial activity against third stage infective larvae (L3) form of Brugia malayi infected in Mastomys coucha assessed as female sterilizing efficacy at 100 mg/kg, sc administered for 5 days measured on day 91 post-initiation of drug treatment (Rvb = 23%) | Brugia malayi | 2 | organism-based format | Scientific Literature | ||
13. | ALA3269491 | T | Toxicity in Mastomys coucha infected with third stage infective larvae (L3) form of Brugia malayi assessed as normal behaviour at at 100 mg/kg, sc administered for 5 days measured on day 91 post-initiation of drug treatment | Mastomys coucha | 2 | organism-based format | Scientific Literature |