| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3269755 | B | Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) by fluorescence plate reader analysis | Homo sapiens | 4 | ALA3259785 | single protein format | Scientific Literature | |
| 2. | ALA3269757 | B | Inhibition of EPAC1 (unknown origin) assessed as cAMP-mediated GEF activity | Homo sapiens | 1 | ALA3259785 | single protein format | Scientific Literature | |
| 3. | ALA3595079 | B | Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) | Homo sapiens | 1 | ALA3593245 | single protein format | Scientific Literature | |
| 4. | ALA3595148 | B | Antagonist activity at EPAC2 (unknown origin) assessed as cAMP-induced guanine nucleotide exchange factor activity | Homo sapiens | 1 | ALA3593245 | single protein format | Scientific Literature | |
| 5. | ALA3595149 | B | Antagonist activity at EPAC1 (unknown origin) assessed as cAMP-induced guanine nucleotide exchange factor activity | Homo sapiens | 1 | ALA3593245 | single protein format | Scientific Literature | |
| 6. | ALA3595150 | B | Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay | Mus musculus | 49 | ALA3593245 | single protein format | Scientific Literature | |
| 7. | ALA3595151 | B | Ratio of cAMP IC50 to compound IC50 for displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay | Mus musculus | 36 | ALA3593245 | single protein format | Scientific Literature | |
| 8. | ALA3595153 | B | Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity | Homo sapiens | 13 | ALA3593245 | single protein format | Scientific Literature | |
| 9. | ALA3595154 | P | Aqueous solubility of the compound in water after 24 hrs by HPLC analysis | 8 | ALA3593245 | small-molecule physicochemical format | Scientific Literature | ||
| 10. | ALA3595155 | P | Aqueous solubility of the compound in ethanol after 24 hrs by HPLC analysis | 8 | ALA3593245 | small-molecule physicochemical format | Scientific Literature | ||
| 11. | ALA3734567 | B | Inhibition of Tet-induced Flag-tagged mouse TRPM7 expressed in HEK293 cells assessed as inhibition of channel-mediated cell death in presence of Mg2+ incubated for 24 to 48 hrs by propidium iodide uptake assay | Mus musculus | 359 | ALA3727350 | cell-based format | Patent Bioactivity Data | |
| 12. | ALA3810793 | B | Inhibition of EPAC2 (unknown origin) assessed as reduction in cAMP-mediated guanine nucleotide exchange factor activity in presence of C-terminal truncated Rap1B (1 to 167 residues)-BODIPY-GDP by microplate reader analysis | Homo sapiens | 5 | ALA3808331 | single protein format | Scientific Literature | |
| 13. | ALA3810794 | B | Inhibition of recombinant C-terminal FLAG/HA-tagged EPAC2 (unknown origin) expressed in retrovirus infected human HeLaS3 cells assessed as reduction in cAMP-mediated guanine nucleotide exchange factor activity in presence of C-terminal truncated Rap1B (1 to 167 residues)-Mant-GDP by spectrofluorometric analysis | Homo sapiens | 1 | ALA3808331 | cell-based format | Scientific Literature | |
| 14. | ALA3810795 | B | Inhibition of recombinant C-terminal FLAG/HA-tagged EPAC1 (unknown origin) expressed in retrovirus infected human HeLaS3 cells assessed as reduction in cAMP-mediated guanine nucleotide exchange factor activity in presence of C-terminal truncated Rap1B (1 to 167 residues)-Mant-GDP by spectrofluorometric analysis | Homo sapiens | 1 | ALA3808331 | cell-based format | Scientific Literature | |
| 15. | ALA4021027 | B | Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide exchange activity by 8-NBD-cAMP competition assay | Homo sapiens | 31 | ALA4020713 | single protein format | Scientific Literature | |
| 16. | ALA4021028 | B | Antagonist activity at mouse EPAC2 assessed as inhibition of EPAC2-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide exchange activity by 8-NBD-cAMP competition assay | Mus musculus | 11 | ALA4020713 | single protein format | Scientific Literature | |
| 17. | ALA4021029 | B | Ratio of IC50 for recombinant human full length EPAC1 to IC50 for mouse EPAC2 | 1 | ALA4020713 | assay format | Scientific Literature | ||
| 18. | ALA4178330 | B | Inhibition of EPAC1 (unknown origin) | Homo sapiens | 1 | ALA4177535 | single protein format | Scientific Literature | |
| 19. | ALA4178331 | B | Inhibition of EPAC2 (unknown origin) | Homo sapiens | 1 | ALA4177535 | single protein format | Scientific Literature | |
| 20. | ALA4181269 | B | Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange activity | Homo sapiens | 24 | ALA4177657 | single protein format | Scientific Literature |
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