Antihypertensive activity in spontaneous hypertensive rat model assessed as decrease in blood pressure at 100 mg/kg, po administered for 2 to 4 days measured on day 2 to day 4
Antihypertensive activity in spontaneous hypertensive rat model assessed as decrease in blood pressure at 200 mg/kg, po administered for 2 to 4 days measured on day 2 to day 4
Antihypertensive activity in unanesthetized renal hypertensive Mongrel dog model assessed as change in mean blood pressure at 30 mg/kg, po qd measured on day 1
Antihypertensive activity in unanesthetized renal hypertensive Mongrel dog model assessed as change in mean blood pressure at 30 mg/kg, po qd measured on day 2
Antihypertensive activity in unanesthetized renal hypertensive Mongrel dog model assessed as change in mean blood pressure at 30 mg/kg, po qd measured on day 3
Antihypertensive activity in normotensive squirrel monkey model assessed as decrease in systolic blood pressure at 100 mg/kg, po qd measured on day 2 by sphygmomanometry
Antihypertensive activity in normotensive squirrel monkey model assessed as decrease in systolic blood pressure at 100 mg/kg, po qd measured on day 1 by sphygmomanometry
Antihypertensive activity in normotensive squirrel monkey model assessed as decrease in systolic blood pressure at 100 mg/kg, po qd measured on day 3 by sphygmomanometry