# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA703726 | F | Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. | Mus musculus | 771 | ALA1122023 | cell-based format | Scientific Literature | |
2. | ALA813896 | A | Compound concentration in mole/kg/day lethal to 10% of mice | Mus sp. | 771 | ALA1122023 | organism-based format | Scientific Literature | |
3. | ALA5051789 | F | Antiproliferative activity against human MDA-MB-231 cells at 2 uM assessed as induction of cells death and measured after 24 hrs by Cell Titer Blue assay relative to control | Homo sapiens | 1 | ALA5050862 | cell-based format | Patent Bioactivity Data | |
4. | ALA5051790 | F | Antiproliferative activity against human HeLa cells transfected with LY6K-shRNA2 assessed as fold increase in cell death and measured by Cell Titer Blue assay | Homo sapiens | 1 | ALA5050862 | cell-based format | Patent Bioactivity Data | |
5. | ALA5051791 | F | Antiproliferative activity against human MDA-MB-231 cells transfected with LY6K-ShRNA2 at 2 uM assessed as induction of cells death and measured after 24 hrs by Cell Titer Blue assay relative to control | Homo sapiens | 1 | ALA5050862 | cell-based format | Patent Bioactivity Data | |
6. | ALA5051792 | F | Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by Cell Titer Blue assay | Homo sapiens | 1 | ALA5050862 | cell-based format | Patent Bioactivity Data | |
7. | ALA5051793 | F | Antiproliferative activity against human Hs-578T cells after 24 hrs by Cell Titer Blue assay | Homo sapiens | 1 | ALA5050862 | cell-based format | Patent Bioactivity Data | |
8. | ALA5051794 | F | Antiproliferative activity against human BT-549 cells after 24 hrs by Cell Titer Blue assay | Homo sapiens | 1 | ALA5050862 | cell-based format | Patent Bioactivity Data | |
9. | ALA5051795 | F | Antiproliferative activity against human OVCAR-8 cells after 24 hrs by Cell Titer Blue assay | Homo sapiens | 1 | ALA5050862 | cell-based format | Patent Bioactivity Data | |
10. | ALA5051796 | F | Antitumor activity against mouse 4T1 cells allografted in syngenetic BALB/c mouse assessed as tumor growth inhibition at 5 mg/kg, IT(Intratumoral) measured at day 3 | Mus musculus | 1 | ALA5050862 | organism-based format | Patent Bioactivity Data | |
11. | ALA5051798 | F | Antitumor immunity in C57BL/6 mouse xenografted with mouse EO771 cells assessed as reduction in tumor growth at 10 mg/kg, ip administered every 3rd day | Mus musculus | 1 | ALA5050862 | organism-based format | Patent Bioactivity Data | |
12. | ALA5051801 | F | Down-regulation of PD-L1 expression in human MDA-MB-231 cells at 2 uM measured after 30 mins by Western blot analysis | Homo sapiens | 2 | ALA5050862 | cell-based format | Patent Bioactivity Data | |
13. | ALA5051802 | B | Inhibition of TGF-beta1-induced Smad2/3 phopshorylation in human MDA-MB-231 cells at 2 uM measured after 30 mins by Western blot analysis | Homo sapiens | 2 | ALA5050862 | cell-based format | Patent Bioactivity Data | |
14. | ALA5051803 | B | Inhibition of IFN-gamma-induced Stat1 phopshorylation in human MDA-MB-231 cells at 2 uM measured after 30 mins by Western blot analysis | Homo sapiens | 2 | ALA5050862 | cell-based format | Patent Bioactivity Data | |
15. | ALA5051804 | F | Antitumor activity against mouse 4T1 cells xenografted mouse assessed as decrease in Cd11b and Gr-1-dual positive lymphocytes in peripheral blood at 50 mg/kg, iv | Mus musculus | 1 | ALA5050862 | organism-based format | Patent Bioactivity Data | |
16. | ALA5051805 | F | Antitumor activity against mouse 4T1 cells xenografted mouse assessed as decrease in myeloid-derived suppressor cells (MDSCs) in peripheral blood at 50 mg/kg, iv | Mus musculus | 1 | ALA5050862 | organism-based format | Patent Bioactivity Data | |
17. | ALA5051806 | F | Cell cycle arrest in mouse 4T1 cells assessed as accumulation at sub G1 phase at 1 uM (Rvb = 0.4%) | Mus musculus | 1 | ALA5050862 | cell-based format | Patent Bioactivity Data | |
18. | ALA5051807 | F | Cell cycle arrest in mouse 4T1 cells assessed as accumulation at G1 phase at 1 uM (Rvb = 58.1%) | Mus musculus | 1 | ALA5050862 | cell-based format | Patent Bioactivity Data | |
19. | ALA5051808 | F | Cell cycle arrest in mouse 4T1 cells assessed as accumulation at S phase at 1 uM (Rvb = 18.8%) | Mus musculus | 1 | ALA5050862 | cell-based format | Patent Bioactivity Data | |
20. | ALA5051809 | F | Cell cycle arrest in mouse 4T1 cells assessed as accumulation at G2 phase at 1 uM (Rvb = 22.7%) | Mus musculus | 1 | ALA5050862 | cell-based format | Patent Bioactivity Data |