| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3625951 | B | Inhibition of SIRT6 in human BxPC-3 cells assessed as increase in H3K9 acetylation by immunoblotting assay relative to control | Homo sapiens | 4 | ALA3621196 | cell-based format | Scientific Literature | |
| 2. | ALA3625953 | B | Inhibition of human SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay | Homo sapiens | 14 | ALA3621196 | single protein format | Scientific Literature | |
| 3. | ALA3625954 | B | Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by luminescence assay | Homo sapiens | 14 | ALA3621196 | single protein format | Scientific Literature | |
| 4. | ALA3625955 | B | Inhibition of human SIRT1 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay | Homo sapiens | 4 | ALA3621196 | single protein format | Scientific Literature | |
| 5. | ALA3625956 | B | Inhibition of human SIRT2 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay | Homo sapiens | 4 | ALA3621196 | single protein format | Scientific Literature | |
| 6. | ALA3625957 | B | Selectivity ratio of IC50 for human SIRT1 to IC50 for human SIRT6 | Homo sapiens | 4 | ALA3621196 | assay format | Scientific Literature | |
| 7. | ALA3625958 | B | Selectivity ratio of IC50 for human SIRT2 to IC50 for human SIRT6 | Homo sapiens | 4 | ALA3621196 | assay format | Scientific Literature | |
| 8. | ALA3625959 | B | Competitive inhibition of human recombinant SIRT6 deacetylase activity using NAD+ as a substrate at 50 uM by double-reciprocal plot analysis | Homo sapiens | 3 | ALA3621196 | single protein format | Scientific Literature | |
| 9. | ALA3625960 | B | Competitive inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate at 50 uM by double-reciprocal plot analysis | Homo sapiens | 3 | ALA3621196 | single protein format | Scientific Literature | |
| 10. | ALA3625961 | B | Inhibition of SIRT6 in human BxPC-3 cells assessed as increase in radiolabelled glucose uptake at 100 uM after 18 hrs by fluorescence plate reader relative to control | Homo sapiens | 4 | ALA3621196 | cell-based format | Scientific Literature | |
| 11. | ALA3625962 | B | Inhibition of SIRT6 in rat L6 cells assessed as increase in radiolabelled glucose uptake at 100 uM after 18 hrs by fluorescence plate reader relative to control | Rattus norvegicus | 4 | ALA3621196 | cell-based format | Scientific Literature | |
| 12. | ALA3625963 | B | Inhibition of SIRT6 in rat L6 cells assessed as increase in 2-NBDG uptake at 100 uM after 18 hrs by fluorescence plate reader relative to control | Rattus norvegicus | 4 | ALA3621196 | cell-based format | Scientific Literature | |
| 13. | ALA3625964 | B | Inhibition of SIRT6 in human PBMC assessed as inhibition of PHA-induced TNF alpha production at 200 uM after 3 days by ELISA | Homo sapiens | 1 | ALA3621196 | single protein format | Scientific Literature | |
| 14. | ALA3625966 | B | Inhibition of SIRT6 in human PBMC assessed as inhibition of MLR-induced TNF alpha production at 200 uM after 3 days by ELISA | Homo sapiens | 1 | ALA3621196 | single protein format | Scientific Literature | |
| 15. | ALA3626082 | A | Cytotoxicity against PHA-induced human PBMC assessed as cell viability using propidium iodide by flow cytometry | Homo sapiens | 3 | ALA3621196 | cell-based format | Scientific Literature | |
| 16. | ALA3626083 | A | Cytotoxicity against MLR-induced human PBMC assessed as cell viability using propidium iodide by flow cytometry | Homo sapiens | 3 | ALA3621196 | cell-based format | Scientific Literature | |
| 17. | ALA3626084 | A | Cytotoxicity against human HEK293 cells assessed as cell viability using propidium iodide by flow cytometry | Homo sapiens | 3 | ALA3621196 | cell-based format | Scientific Literature | |
| 18. | ALA3626085 | F | Induction of DNA damage in human BRCA2-deficient Capan1 cells assessed as increase in gammaH2AX levels at 100 uM after 24 hrs by confocal microscopy | Homo sapiens | 1 | ALA3621196 | cell-based format | Scientific Literature | |
| 19. | ALA3626087 | B | Inhibition of human SIRT6 in BRCA2-deficient Capan1 cells assessed as potentiation of olaparib-induced DNA damage by measuring gammaH2AX levels at 100 uM after 24 hrs by confocal microscopy | Homo sapiens | 1 | ALA3621196 | cell-based format | Scientific Literature | |
| 20. | ALA3626089 | B | Inhibition of human SIRT6 in BRCA2-deficient Capan1 cells assessed as potentiation of olaparib-induced DNA damage by measuring gammaH2AX levels at 100 uM after 24 hrs by flow cytometry analysis | Homo sapiens | 1 | ALA3621196 | cell-based format | Scientific Literature |
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