# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3292894 | B | Inhibition of chloroquine-resistant Plasmodium falciparum Dd2 CRT expressed in Xenopus laevis oocytes plasma membrane assessed as reduction of [3H]-chloroquine transportation at 100 uM after 1 to 2 hrs | Plasmodium falciparum Dd2 | 28 | ALA3286244 | cell-based format | Scientific Literature | |
2. | ALA3292895 | B | Inhibition of chloroquine-sensitive Plasmodium falciparum D10 CRT expressed in Xenopus laevis oocytes plasma membrane assessed as reduction of [3H]-chloroquine transportation at 100 uM after 1 to 2 hrs | Plasmodium falciparum D10 | 24 | ALA3286244 | cell-based format | Scientific Literature | |
3. | ALA3292896 | B | Inhibition of chloroquine-resistant Plasmodium falciparum Dd2 CRT expressed in Xenopus laevis oocytes plasma membrane assessed as reduction of [3H]-chloroquine transportation after 1 to 2 hrs | Plasmodium falciparum Dd2 | 8 | ALA3286244 | cell-based format | Scientific Literature | |
4. | ALA3292897 | F | Antiplasmodial activity against Plasmodium falciparum C2GC03 expressing wild-type pfcrt allele assessed as parasite growth at 800 nM after 72 hrs by SYBR Green I-based fluorescence assay relative to control | Plasmodium falciparum | 6 | ALA3286244 | organism-based format | Scientific Literature | |
5. | ALA3292898 | F | Antiplasmodial activity against Plasmodium falciparum C4Dd2 expressing chloroquine-resistance-conferring pfcrt alleles assessed as parasite growth at 800 nM after 72 hrs by SYBR Green I-based fluorescence assay relative to control | Plasmodium falciparum | 6 | ALA3286244 | organism-based format | Scientific Literature | |
6. | ALA3292899 | F | Antiplasmodial activity against Plasmodium falciparum C67G8 expressing chloroquine-resistance-conferring pfcrt alleles assessed as parasite growth at 800 nM after 72 hrs by SYBR Green I-based fluorescence assay relative to control | Plasmodium falciparum | 6 | ALA3286244 | organism-based format | Scientific Literature | |
7. | ALA3292900 | F | Response modification index, ratio of IC50 for Plasmodium falciparum C2GC03 expressing wild-type pfcrt allele in presence of drug to IC50 for Plasmodium falciparum C2GC03 expressing wild-type pfcrt allele in absence of 800 nM of drug | Plasmodium falciparum | 6 | ALA3286244 | organism-based format | Scientific Literature | |
8. | ALA3292901 | F | Response modification index, ratio of IC50 for Plasmodium falciparum C4Dd2 expressing chloroquine-resistance-conferring pfcrt alleles in presence of drug to IC50 for Plasmodium falciparum C4Dd2 expressing chloroquine-resistance-conferring pfcrt alleles in absence of 800 nM of drug | Plasmodium falciparum | 6 | ALA3286244 | organism-based format | Scientific Literature | |
9. | ALA3292902 | F | Response modification index, ratio of IC50 for Plasmodium falciparum C67G8 expressing chloroquine-resistance-conferring pfcrt alleles in presence of drug to IC50 for Plasmodium falciparum C67G8 expressing chloroquine-resistance-conferring pfcrt alleles in absence of 800 nM of drug | Plasmodium falciparum | 6 | ALA3286244 | organism-based format | Scientific Literature | |
10. | ALA3292903 | B | Inhibition of CTR in Plasmodium falciparum C2GC03 expressing wild-type pfcrt allele assessed as increase of accumulation of [3H]-chloroquine level at 1 uM after 1 hr | Plasmodium falciparum | 26 | ALA3286244 | single protein format | Scientific Literature | |
11. | ALA3292904 | B | Inhibition of CTR in Plasmodium falciparum C4Dd2 expressing chloroquine-resistance-conferring pfcrt alleles assessed as increase of accumulation of [3H]-chloroquine level at 1 uM after 1 hr relative to control | Plasmodium falciparum | 6 | ALA3286244 | single protein format | Scientific Literature | |
12. | ALA3292905 | B | Inhibition of CTR in Plasmodium falciparum C67G8 expressing chloroquine-resistance-conferring pfcrt alleles assessed as increase of accumulation of [3H]-chloroquine level at 1 uM after 1 hr relative to control | Plasmodium falciparum | 6 | ALA3286244 | single protein format | Scientific Literature |