| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3292499 | B | Inhibition of TPH-1-mediated serotonin biosynthesis in rat RBL2H3 cells at 10 uM after 48 hrs by RP-HPLC analysis relative to control | Rattus norvegicus | 53 | cell-based format | Scientific Literature | ||
| 2. | ALA3292751 | B | Inhibition of TPH-1-mediated serotonin biosynthesis in rat RBL2H3 cells after 48 hrs by RP-HPLC analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA3292752 | A | Cytotoxicity against rat RBL2H3 cells by MTT assay | Rattus norvegicus | 53 | cell-based format | Scientific Literature | ||
| 4. | ALA3292753 | B | Inhibition of TPH-1 in rat RBL2H3 cells assessed as downregulation of TPH-1 protein expression by ELISA | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA3292754 | B | Inhibition of TPH-1 in rat RBL2H3 cells assessed as downregulation of TPH-1 mRNA expression at 10 uM by qRT-PCR analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3292755 | B | Inhibition of TPH-2-mediated serotonin biosynthesis in rat PC12 cells after 48 hrs by RP-HPLC analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA3292756 | A | Cytotoxicity against rat PC12 cells by MTT assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA3292757 | B | Inhibition of TPH-2 in rat PC12 cells assessed as downregulation of TPH-2 protein expression at 10 uM by ELISA | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA3292758 | B | Inhibition of TPH-2 in rat PC12 cells assessed as downregulation of TPH-2 mRNA expression at 10 uM after 24 to 48 hrs by qRT-PCR analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA3292759 | B | Selectivity ratio of IC50 for TPH-2 in rat PC12 cells to IC50 for TPH-1 in rat RBL2H3 cells | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA3292760 | B | Binding affinity to TPH-1 (unknown origin) by SPR analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA3292761 | F | Antiosteoporotic activity in ovariectomized po dosed rat assessed as decrease in serum serotonin level administered for 30 days by HPLC analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA3292762 | F | Effect on brain serotonin level in ovariectomized rat at 1 to 20 mg/kg/day, po for 30 days by RP-HPLC analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA3292763 | F | Antiosteoporotic activity in ovariectomized rat assessed as decrease in gut serotonin level at 10 mg/kg, po qd for 7 days by HPLC analysis relative to control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA3292764 | F | Antiosteoporotic activity in ovariectomized rat assessed as decrease in gut serotonin level at 20 mg/kg, po qd for 7 days by HPLC analysis relative to control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3292765 | A | Drug uptake in ovariectomized rat brain at 10 to 20 mg/kg, po qd for 7 days by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3292766 | F | Antiosteoporotic activity in ovariectomized rat assessed as increase in trabecular bone volume fraction at 1 mg/kg/day, po for 30 days by microcomputed tomographic analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3292767 | F | Antiosteoporotic activity in ovariectomized rat assessed as increase in trabecular thickness at 1 mg/kg/day, po for 30 days by microcomputed tomographic analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3292768 | F | Antiosteoporotic activity in ovariectomized rat assessed as increase in trabecular number at 1 mg/kg/day, po for 30 days by microcomputed tomographic analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3292769 | F | Antiosteoporotic activity in ovariectomized rat assessed as increase in bone mineral density at 1 mg/kg/day, po for 30 days by microcomputed tomographic analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!