# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3297474 | B | Binding affinity to human RXR-alpha-ligand binding domain homodimers by fluorescence quenching method | Homo sapiens | 8 | ALA3286246 | single protein format | Scientific Literature | |
2. | ALA3297475 | B | Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after transfection measured 48 hrs post-transfection by dual luciferase reporter assay | Homo sapiens | 8 | ALA3286246 | cell-based format | Scientific Literature | |
3. | ALA3297476 | B | Agonist activity at Gal4-fused human RAR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity at 1 uM treated 24 hrs after transfection measured 48 hrs post-transfection by dual luciferase reporter assay | Homo sapiens | 5 | ALA3286246 | cell-based format | Scientific Literature | |
4. | ALA3297477 | B | Agonist activity at human RXR-alpha-ligand binding domain homodimers assessed as coactivator recruitment by measuring GRIP1 binding to receptor by isothermal titration calorimetry | Homo sapiens | 8 | ALA3286246 | single protein format | Scientific Literature | |
5. | ALA3297478 | B | Agonist activity at RXR-alpha in rat R3KE cells infected with oncogene KLF4-ER assessed as inhibition of KLF4-mediated oncogenic transformation | Rattus norvegicus | 8 | ALA3286246 | cell-based format | Scientific Literature | |
6. | ALA3297480 | A | Induction of hyperlipidemia in N-methylnitrosurea-induced mammary cancer Sprague-Dawley rat model assessed as increase in serum triglyceride level at 200 mg/kg administered through diet for 7 days | Rattus norvegicus | 6 | ALA3286246 | organism-based format | Scientific Literature | |
7. | ALA3297482 | F | Anticancer activity against N-methylnitrosurea-induced mammary cancer in Sprague-Dawley rat assessed as decrease in proliferation index at 200 mg/kg administered through diet for 7 days by BrdU incorporation assay | Rattus norvegicus | 6 | ALA3286246 | organism-based format | Scientific Literature | |
8. | ALA3626726 | B | Agonist activity at human RXRalpha LBD expressed in HEK293 cells transfected with Gal4 reporter assessed as increase of transcription at 10'-6 M by dual luciferase reporter assay relative to control | Homo sapiens | 10 | ALA3621048 | cell-based format | Scientific Literature | |
9. | ALA3626728 | F | Anticancer activity in methylnitrosourea-induced mammary cancer model of Sprague-Dawley rat assessed as reduction of cancer weight at 200 mg/kg treated with diet for 3 months relative to control | Rattus norvegicus | 12 | ALA3621048 | organism-based format | Scientific Literature | |
10. | ALA3626732 | T | Toxicity in methylnitrosourea-induced mammary cancer model of Sprague-Dawley rat assessed as reduction of body weight gain at 200 mg/kg treated with diet for 1 month | Rattus norvegicus | 1 | ALA3621048 | organism-based format | Scientific Literature | |
11. | ALA3626733 | T | Toxicity in methylnitrosourea-induced mammary cancer model of Sprague-Dawley rat assessed as skin reddening at 200 mg/kg treated with diet for 1 month | Rattus norvegicus | 1 | ALA3621048 | organism-based format | Scientific Literature | |
12. | ALA3626734 | T | Toxicity in methylnitrosourea-induced mammary cancer model of Sprague-Dawley rat assessed as mucus membrane dryness at 200 mg/kg treated with diet for 1 month | Rattus norvegicus | 1 | ALA3621048 | organism-based format | Scientific Literature | |
13. | ALA3626735 | F | Anticancer activity in methylnitrosourea-induced mammary cancer model of Sprague-Dawley rat at 100 mg/kg treated with diet for 3 months relative to control | Rattus norvegicus | 1 | ALA3621048 | organism-based format | Scientific Literature | |
14. | ALA3626736 | T | Toxicity in methylnitrosourea-induced mammary cancer model of Sprague-Dawley rat assessed as increase of triglyceride level in serum at 100 mg/kg treated with diet for 3 months relative to control | Rattus norvegicus | 1 | ALA3621048 | organism-based format | Scientific Literature | |
15. | ALA3627127 | F | Anticancer activity in methylnitrosourea-induced mammary cancer model of Sprague-Dawley rat assessed as reduction of cancer number at 100 mg/kg treated with diet for 3 months relative to control | Rattus norvegicus | 1 | ALA3621048 | organism-based format | Scientific Literature |