| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3295126 | B | Inhibition of mPGES1-mediated PGE2 production in microsomes of IL-1beta stimulated human A549 cells assessed as residual activity preincubated at 10 uM for 15 mins by RP-HPLC analysis relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 2. | ALA3295127 | B | Inhibition of human recombinant 5-LO expressed in Escherichia coli Bl21 (DE3) using arachidonic acid as substrate preincubated for 10 mins measured after 10 mins by RP-HPLC analysis | Homo sapiens | 16 | assay format | Scientific Literature | ||
| 3. | ALA3295128 | B | Inhibition of 5-LO in human neutrophils using arachidonic acid as substrate preincubated for 15 mins measured after 10 mins by HPLC analysis | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 4. | ALA3295130 | F | Antioxidant activity assessed as DPPH free radical scavenging activity at 10 uM after 30 mins by UPLC-MS/MS analysis by spectrophotometric analysis | 16 | assay format | Scientific Literature | |||
| 5. | ALA3295131 | P | Aqueous stability of the compound in at 2 uM in 10 mM aqueous ammonium bicarbonate at pH 7.9 assessed as formation of trans-6-(4'-hydroxy-3'-methoxyphenyl)-2,4-dioxo-5-hexenal measured as residual amount of compound by reversed phase liquid chromatography-coupled mass spectrometry | 16 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA3295132 | B | Inhibition of COX1-mediated PGE2 production in human platelets assessed as residual activity by measuring formation of 12-HHT from arachidonic acid preincubated at 10 uM for 5 mins measured after 5 mins by RP-HPLC analysis relative to control | Homo sapiens | 12 | assay format | Scientific Literature | ||
| 7. | ALA3295134 | B | Inhibition of purified ovine COX-1 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid preincubated at 10 uM for 5 mins before substrate addition measured after 5 mins by HPLC analysis relative to control | Ovis aries | 14 | single protein format | Scientific Literature | ||
| 8. | ALA3295135 | B | Inhibition of purified human COX-2 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid preincubated at 10 uM for 5 mins before substrate addition measured after 5 mins by HPLC analysis relative to control | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 9. | ALA3295136 | B | Inhibition of 12-LO in human neutrophils assessed as residual activity relative to control | Homo sapiens | 12 | single protein format | Scientific Literature | ||
| 10. | ALA3295138 | B | Inhibition of 15-LO in human neutrophils assessed as residual activity relative to control | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 11. | ALA3295139 | B | Inhibition of TNFalpha-induced NF-kappaB transcriptional activity in human 5.1 cells after 6 hrs | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 12. | ALA3295140 | B | Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 13. | ALA3295141 | B | Activation of Nrf2 transcriptional activity in human LNCaP cells after 6 hrs by luciferase reporter gene assay relative to tert-butylhydroquinone | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 14. | ALA3295142 | A | Cytotoxicity against human LNCAP cells assessed as cell viability after 24 hrs by MTT assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 15. | ALA3295143 | A | Cytotoxicity against human PBMCs assessed as cell viability after 24 hrs by MTT assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 16. | ALA3295144 | B | Inhibition of 5-LO-mediated LTB4 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition measured after 30 mins by UPLC-MS/MS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 17. | ALA3295145 | B | Inhibition of 5-LO-mediated 5-HETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition measured after 30 mins by UPLC-MS/MS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 18. | ALA3295146 | B | Inhibition of 5-LO-mediated 5,12-DiHETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition measured after 30 mins by UPLC-MS/MS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 19. | ALA3295147 | B | Ratio of curcumin IC50 to compound IC50 for 5-LO-mediated LTB4 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition measured after 30 mins by UPLC-MS/MS analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 20. | ALA3295148 | B | Ratio of curcumin IC50 to compound IC50 for 5-LO-mediated 5-HETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition measured after 30 mins by UPLC-MS/MS analysis | Homo sapiens | 4 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!