# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3294635 | Binding | Inhibition of recombinant human AHCY using SAH as substrate assessed as formation of homocysteine after 10 mins | Homo sapiens | 24 | ALA3286270 | single protein format | Scientific Literature | |
2. | ALA3294636 | Binding | Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysis | Homo sapiens | 20 | ALA3286270 | cell-based format | Scientific Literature | |
3. | ALA3294639 | ADME | Clearance in rat | Rattus norvegicus | 1 | ALA3286270 | organism-based format | Scientific Literature | |
4. | ALA3294640 | ADME | Clearance in dog | Canis lupus familiaris | 1 | ALA3286270 | organism-based format | Scientific Literature | |
5. | ALA3294641 | ADME | Half life in rat | Rattus norvegicus | 1 | ALA3286270 | organism-based format | Scientific Literature | |
6. | ALA3294642 | ADME | Half life in dog | Canis lupus familiaris | 1 | ALA3286270 | organism-based format | Scientific Literature | |
7. | ALA3294643 | ADME | Oral bioavailability in rat | Rattus norvegicus | 1 | ALA3286270 | organism-based format | Scientific Literature | |
8. | ALA3294644 | ADME | Oral bioavailability in dog | Canis lupus familiaris | 1 | ALA3286270 | organism-based format | Scientific Literature | |
9. | ALA3294645 | ADME | Plasma protein binding in human | Homo sapiens | 1 | ALA3286270 | cell-free format | Scientific Literature | |
10. | ALA3294646 | ADME | Plasma protein binding in rat | Rattus norvegicus | 1 | ALA3286270 | cell-free format | Scientific Literature | |
11. | ALA3294647 | Physicochemical | Solubility of the compound at pH 7 | 1 | ALA3286270 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA3294648 | Binding | Activity of adenosine deaminase (unknown origin) | Homo sapiens | 1 | ALA3286270 | single protein format | Scientific Literature | |
13. | ALA3294649 | Binding | Activity of adenosine kinase (unknown origin) | Homo sapiens | 1 | ALA3286270 | single protein format | Scientific Literature | |
14. | ALA3294650 | Functional | Antialzheimer activity in ip dosed rat assessed as reduction of homocysteine level in brain after 1 to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA3286270 | organism-based format | Scientific Literature | |
15. | ALA3294651 | Functional | Antialzheimer activity in ip dosed rat assessed as reduction of homocysteine level in plasma after 1 to 24 hrs | Rattus norvegicus | 1 | ALA3286270 | organism-based format | Scientific Literature |