# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3291853 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 infected in human THP1 cells assessed as reduction in CFU after 21 to 28 days | Mycobacterium tuberculosis | 29 | ALA3286390 | organism-based format | Scientific Literature | |
2. | ALA3291854 | B | Inhibition of Mycobacterium smegmatis thioredoxin 6xHis-tagged decaprenylphosphoryl-beta-D-ribose2'-epimerase 1 overexpressed in Escherichia coli rosetta cells using farnesyl-phosphoryl-beta-D-ribofuranose as substrate | Mycolicibacterium smegmatis | 29 | ALA3286390 | cell-based format | Scientific Literature | |
3. | ALA3291855 | B | Inhibition of PDE6 (unknown origin) | Homo sapiens | 13 | ALA3286390 | protein format | Scientific Literature | |
4. | ALA3291856 | A | Intrinsic clearance in mouse liver microsomes | Mus musculus | 22 | ALA3286390 | assay format | Scientific Literature | |
5. | ALA3291857 | P | Octanol-water partition coefficient, log D of the compound at pH 7.4 by shake flask method | 22 | ALA3286390 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA3292117 | F | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as growth inhibition after 5 days by microdilution method | Mycobacterium tuberculosis | 11 | ALA3286390 | organism-based format | Scientific Literature | |
7. | ALA3292118 | F | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 harboring DprE1 OE mutant assessed as growth inhibition after 5 days by microdilution method | Mycobacterium tuberculosis | 11 | ALA3286390 | organism-based format | Scientific Literature | |
8. | ALA3292119 | F | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 harboring DprE1 C387S mutant assessed as growth inhibition after 5 days by microdilution method | Mycobacterium tuberculosis | 11 | ALA3286390 | organism-based format | Scientific Literature | |
9. | ALA3292120 | F | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 harboring DprE1 C387G mutant assessed as growth inhibition after 5 days by microdilution method | Mycobacterium tuberculosis | 11 | ALA3286390 | organism-based format | Scientific Literature | |
10. | ALA3292121 | F | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 harboring DprE1 Y314H mutant assessed as growth inhibition after 5 days by microdilution method | Mycobacterium tuberculosis | 11 | ALA3286390 | organism-based format | Scientific Literature | |
11. | ALA3292122 | F | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 harboring DprE1 Rv1937/F426C mutant assessed as growth inhibition after 5 days by microdilution method | Mycobacterium tuberculosis | 11 | ALA3286390 | organism-based format | Scientific Literature | |
12. | ALA3292123 | P | Aqueous solubility of the compound in phosphate buffer at pH 7.4 after 24 hrs by UV-MS analysis | 7 | ALA3286390 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA3292124 | A | Unbound fraction in human plasma | Homo sapiens | 7 | ALA3286390 | cell-free format | Scientific Literature | |
14. | ALA3292125 | A | Permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 7 | ALA3286390 | cell-based format | Scientific Literature | |
15. | ALA3292126 | A | Inhibition of human CYP2D6 | Homo sapiens | 7 | ALA3286390 | single protein format | Scientific Literature | |
16. | ALA3292127 | A | Inhibition of human CYP2C19 | Homo sapiens | 7 | ALA3286390 | single protein format | Scientific Literature | |
17. | ALA3292128 | A | Inhibition of human CYP2C9 | Homo sapiens | 7 | ALA3286390 | single protein format | Scientific Literature | |
18. | ALA3292129 | A | Inhibition of human CYP1A2 | Homo sapiens | 7 | ALA3286390 | single protein format | Scientific Literature | |
19. | ALA3292130 | A | Inhibition of human CYP3A4 | Homo sapiens | 7 | ALA3286390 | single protein format | Scientific Literature | |
20. | ALA3292131 | B | Inhibition of human ERG | Homo sapiens | 7 | ALA3286390 | single protein format | Scientific Literature |