| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3378582 | F | Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced calcium mobilization by fluorescence assay | Rattus norvegicus | 24 | ALA3297742 | cell-based format | Scientific Literature | |
| 2. | ALA3378583 | F | Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced calcium mobilization at 30 uM by fluorescence assay relative to glutamate | Rattus norvegicus | 43 | ALA3297742 | cell-based format | Scientific Literature | |
| 3. | ALA3378584 | A | Intrinsic clearance in human microsomes | Homo sapiens | 5 | ALA3297742 | assay format | Scientific Literature | |
| 4. | ALA3378585 | A | Intrinsic clearance in rat microsomes | Rattus norvegicus | 5 | ALA3297742 | assay format | Scientific Literature | |
| 5. | ALA3378586 | A | Fraction unbound in human plasma | Homo sapiens | 5 | ALA3297742 | cell-free format | Scientific Literature | |
| 6. | ALA3378587 | A | Fraction unbound in rat plasma | Rattus norvegicus | 5 | ALA3297742 | cell-free format | Scientific Literature | |
| 7. | ALA3378589 | F | Positive allosteric modulator activity at rat mGlu1 receptor expressed in HEK293 cells assessed as glutamate-induced calcium mobilization treated 140s prior to glutamate challenge by fluorescence assay | Rattus norvegicus | 1 | ALA3297742 | cell-based format | Scientific Literature | |
| 8. | ALA3378590 | B | Positive allosteric modulator activity at rat mGlu2 receptor expressed in HEK293 cells assessed as glutamate-induced GIRK channel-mediated thallium flux treated 140s prior to gluatamate challenge by fluorescence analysis | Rattus norvegicus | 1 | ALA3297742 | cell-based format | Scientific Literature | |
| 9. | ALA3378591 | B | Positive allosteric modulator activity at rat mGlu4 receptor expressed in HEK293 cells assessed as glutamate-induced GIRK channel-mediated thallium flux treated 140s prior to gluatamate challenge by fluorescence analysis | Rattus norvegicus | 1 | ALA3297742 | cell-based format | Scientific Literature | |
| 10. | ALA3378592 | B | Positive allosteric modulator activity at rat mGlu6 receptor expressed in HEK293 cells assessed as glutamate-induced GIRK channel-mediated thallium flux treated 140s prior to gluatamate challenge by fluorescence analysis | Rattus norvegicus | 1 | ALA3297742 | cell-based format | Scientific Literature | |
| 11. | ALA3378593 | B | Positive allosteric modulator activity at rat mGlu7 receptor expressed in HEK293 cells assessed as L-AP4-induced GIRK channel-mediated thallium flux treated 140s prior to L-AP4 challenge by fluorescence analysis | Rattus norvegicus | 1 | ALA3297742 | cell-based format | Scientific Literature | |
| 12. | ALA3379142 | B | Positive allosteric modulator activity at rat mGlu8 receptor expressed in HEK293 cells assessed as glutamate-induced GIRK channel-mediated thallium flux treated 140s prior to glutamate challenge by fluorescence analysis | Rattus norvegicus | 1 | ALA3297742 | cell-based format | Scientific Literature | |
| 13. | ALA3379143 | B | Positive allosteric modulator activity at human mGlu5 receptor | Homo sapiens | 1 | ALA3297742 | single protein format | Scientific Literature | |
| 14. | ALA3379144 | B | Positive allosteric modulator activity at human mGlu5 receptor relative to glutamate | Homo sapiens | 1 | ALA3297742 | single protein format | Scientific Literature | |
| 15. | ALA3379145 | F | Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293 cells assessed as leftward shift in glutamate concentration response curve for calcium mobilization at 30 uM by fluorescence assay | Rattus norvegicus | 1 | ALA3297742 | cell-based format | Scientific Literature | |
| 16. | ALA3379146 | B | Positive allosteric modulator activity at human mGlu5 receptor assessed as leftward shift in glutamate concentration response curve at 10 uM | Homo sapiens | 1 | ALA3297742 | single protein format | Scientific Literature | |
| 17. | ALA3379147 | A | Fraction unbound in rat brain | Rattus norvegicus | 1 | ALA3297742 | tissue-based format | Scientific Literature | |
| 18. | ALA3379148 | A | Inhibition of CYP1A2 in human liver microsomes | Homo sapiens | 1 | ALA3297742 | assay format | Scientific Literature | |
| 19. | ALA3379149 | A | Inhibition of CYP2C9 in human liver microsomes | Homo sapiens | 1 | ALA3297742 | assay format | Scientific Literature | |
| 20. | ALA3379150 | A | Inhibition of CYP2D6 in human liver microsomes | Homo sapiens | 1 | ALA3297742 | assay format | Scientific Literature |
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