| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA814594 | B | Activation of human Thyroid hormone receptor alpha1 (hTRalpha1) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 2. | ALA814595 | B | Half-maximum activation of human Thyroid hormone receptor alpha-1 (hTRalpha1) | 2 | single protein format | Scientific Literature | |||
| 3. | ALA814598 | B | Binding affinity against human Thyroid hormone receptor alpha-1 (hTRalpha1) using radiolabeled T3 | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 4. | ALA814599 | B | Binding affinity of compound was determined against Thyroid hormone receptor alpha1 | 6 | single protein format | Scientific Literature | |||
| 5. | ALA811712 | B | Activation of human Thyroid hormone receptor beta 1 (hTRbeta1) | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 6. | ALA811714 | B | Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 7. | ALA811897 | B | Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3 | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 8. | ALA811899 | B | Binding affinity of compound was determined against thyroid hormone receptor beta 1 | 5 | single protein format | Scientific Literature | |||
| 9. | ALA840701 | B | Selectivity of compound was determined against thyroid hormone receptor | 5 | protein complex format | Scientific Literature | |||
| 10. | ALA949478 | B | Selectivity for human TRbeta1 over human TRalpha1 | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 11. | ALA949479 | B | Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay | Homo sapiens | 27 | single protein format | Scientific Literature | ||
| 12. | ALA949480 | B | Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | Homo sapiens | 27 | single protein format | Scientific Literature | ||
| 13. | ALA949481 | F | Agonist activity at thyroid hormone receptor in Sprague-Dawley rat assessed as liver mGPDH activity at 1 mg/kg administered through osmotic pump infusion per ug protein | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 14. | ALA949482 | F | Agonist activity at thyroid hormone receptor in Sprague-Dawley rat assessed as heart mGPDH activity at 1 mg/kg administered through osmotic pump infusion per ug protein | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 15. | ALA2212120 | B | Binding affinity to human TRalpha1 | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA2212121 | B | Binding affinity to human TRbeta1 | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA2212122 | F | Antidyslipidemic activity in human assessed as reduction in LDL cholesterol at 100 ug administered QD relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3130172 | F | Reduction in LDL-cholesterol in healthy human at 100 ug qd for 2 weeks | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3131650 | B | Selectivity ratio of IC50 for human recombinant TRalpha1 ligand binding domain to IC50 for human recombinant TRbeta1 ligand binding domain | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 20. | ALA3266217 | B | Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 mins assessed as biotin-GRIP1 peptide recruitment by HTRF assay | Homo sapiens | 22 | assay format | Scientific Literature |
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