| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3299551 | B | Antagonist activity at human TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior to cinnamaldehyde addition by FLIPR assay relative to control | Homo sapiens | 35 | cell-based format | Scientific Literature | ||
| 2. | ALA3299552 | B | Antagonist activity at rat TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior to cinnamaldehyde addition by FLIPR assay relative to control | Rattus norvegicus | 6 | cell-based format | Scientific Literature | ||
| 3. | ALA3299553 | B | Antagonist activity at mouse TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior to cinnamaldehyde addition by FLIPR assay relative to control | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 4. | ALA3299554 | B | Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibition of capsaicin-induced calcium flux incubated 10 mins prior to capsaicin addition by FLIPR assay relative to control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 5. | ALA3299555 | B | Antagonist activity at human TRPV3 expressed in CHOK1 cells assessed as inhibition of 2-APB-induced calcium flux incubated 10 mins prior to 2-APB addition by FLIPR assay relative to control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 6. | ALA3299556 | B | Antagonist activity at human TRPM8 expressed in CHOK1 cells assessed as inhibition of menthol-induced calcium flux incubated 10 mins prior to menthol addition by FLIPR assay relative to control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 7. | ALA3299557 | B | Selectivity ratio of IC50 for human TRPV1 expressed in CHOK1 cells to IC50 for human TRPA1 expressed in CHO-TREX cells | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 8. | ALA3299558 | B | Selectivity ratio of IC50 for human TRPV3 expressed in CHOK1 cells to IC50 for human TRPA1 expressed in CHO-TREX cells | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 9. | ALA3299559 | B | Selectivity ratio of IC50 for human TRPM8 expressed in CHOK1 cells to IC50 for human TRPA1 expressed in CHO-TREX cells | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 10. | ALA3299560 | B | Antagonist activity at human TRPA1 expressed in CHO-TREX cells assessed as inhibition of allyl isothiocyanate-induced calcium flux incubated 10 mins prior to allyl isothiocyanate addition by FLIPR assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA3299561 | B | Antagonist activity at human TRPA1 expressed in CHO-TREX cells assessed as inhibition of dibenzo[b,f ][1,4]oxazepine-4-carboxamide-induced calcium flux incubated 10 mins prior to dibenzo[b,f ][1,4]oxazepine-4-carboxamide addition by FLIPR assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA3299563 | A | Clearance in Wistar rat at 5 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA3299566 | A | Volume of distribution at steady state in Wistar rat at 5 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA3299569 | A | Half life in Wistar rat at 5 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA3299571 | A | AUC in Wistar rat at 10 mg/kg, po | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 16. | ALA3299572 | A | Cmax in Wistar rat at 10 mg/kg, po | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 17. | ALA3299573 | A | Tmax in Wistar rat at 10 mg/kg, po | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 18. | ALA3299574 | A | Oral bioavailability in Wistar rat at 10 mg/kg | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 19. | ALA3299575 | F | Reversal of FCA-induced mechanical hyperalgesia in po dosed Wistar rat after 1 hr | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3299576 | F | Reversal of FCA-induced mechanical hyperalgesia in Wistar rat at 10 mg/kg, po after 1 to 3 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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