# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4417891 | F | Growth inhibition of BRCA2-deficient human Capan1 cells at 2.5 to 10 uM following media refreshment every 3 days and measured on day 10 by CellTiter-Glo assay | Homo sapiens | 6 | ALA4417629 | cell-based format | Patent Bioactivity Data | |
2. | ALA4417892 | F | Growth inhibition of BRCA1-deficient human UWB1.289 cells at 2.5 to 10 uM following media refreshment every 3 days and measured on day 10 by CellTiter-Glo assay | Homo sapiens | 6 | ALA4417629 | assay format | Patent Bioactivity Data | |
3. | ALA4417893 | B | Inhibition of RAD51 (unknown origin) assessed as inhibition of DNA pairing by measuring D-loop formation between [32P]-ssDNA and homologous supercoiled pUC19 DNA at 30 uM incubated for 15 mins by gel electrophoresis method relative to control | Homo sapiens | 17 | ALA4417629 | single protein format | Patent Bioactivity Data | |
4. | ALA4417894 | B | Inhibition of RAD52 (unknown origin) assessed as effect on ssDNA annealing using ssDNA oligonucleotide by fluorescence-quenching assay | Homo sapiens | 17 | ALA4417629 | single protein format | Patent Bioactivity Data | |
5. | ALA4417895 | B | Inhibition of RAD52 (unknown origin) assessed as inhibition of DNA pairing using [32P]-ssDNA by measuring D-loop formation incubated for 15 mins by gel electrophoresis method | Homo sapiens | 17 | ALA4417629 | single protein format | Patent Bioactivity Data | |
6. | ALA4417896 | B | Inhibition of RAD51 (unknown origin) assessed as inhibition of DNA pairing by measuring D-loop formation between [32P]-ssDNA and homologous supercoiled pUC19 DNA at 10 times RAD52 IC50 incubated for 15 mins by gel electrophoresis method relative to control | Homo sapiens | 17 | ALA4417629 | single protein format | Patent Bioactivity Data | |
7. | ALA4417897 | B | Binding affinity to salmon sperm DNA incubated for 20 mins by acridine orange displacement based fluorescence polarization assay | Salmonidae | 2 | ALA4417629 | nucleic acid format | Patent Bioactivity Data | |
8. | ALA4417899 | B | Binding affinity to RAD52 (unknown origin) by SPR assay | Homo sapiens | 2 | ALA4417629 | single protein format | Patent Bioactivity Data | |
9. | ALA4417900 | B | Inhibition of RAD52 (unknown origin) expressed in BCR-ABL1-positive and BRCA1-deficient mouse 32Dcl3 cells expressing GFP-RAD52 assessed as reduction in cisplatin-induced RAD52 foci formation at 2.5 uM by AlexaFluor-594 staining based inverted fluorescence microscopy relative to control | Homo sapiens | 2 | ALA4417629 | cell-based format | Patent Bioactivity Data | |
10. | ALA4417901 | B | Inhibition of RAD52 (unknown origin) expressed in BCR-ABL1-positive and BRCA1-deficient mouse 32Dcl3 cells expressing GFP-RAD52 assessed as cisplatin-induced RAD52 foci formation at 2.5 uM by AlexaFluor-594 staining based inverted fluorescence microscopy (Rvb = 38.7 +/- 10%) | Homo sapiens | 2 | ALA4417629 | cell-based format | Patent Bioactivity Data | |
11. | ALA4417902 | B | Inhibition of RAD52 (unknown origin) expressed in BCR-ABL1-positive and BRCA1-deficient mouse 32Dcl3 cells expressing GFP-RAD52 assessed as cisplatin-induced RAD52 foci formation by measuring fraction of cell without foci at 2.5 uM by AlexaFluor-594 staining based inverted fluorescence microscopy (Rvb = 48.4 +/- 6.2%) | Homo sapiens | 2 | ALA4417629 | cell-based format | Patent Bioactivity Data |