| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4185199 | B | Inhibition of HDAC1 in Plasmodium falciparum 3D7 nuclear extract using Ac-RGK(Ac)-AMC fluorogenic peptide as substrate preincubated for 1 hr followed by substrate addition measured after 10 min by fluorescence assay | Plasmodium falciparum 3D7 | 3 | single protein format | Scientific Literature | ||
| 2. | ALA4185200 | B | Inhibition of recombinant HDAC1 in recombinant Plasmodium falciparum at 1 uM using Ac-RGK(Ac)-AMC fluorogenic peptide as substrate preincubated for 1 hr followed by substrate addition measured after 10 min by fluorescence assay | Plasmodium falciparum | 3 | single protein format | Scientific Literature | ||
| 3. | ALA4185201 | F | Antimalarial activity against Plasmodium falciparum infected in human erythrocytes preincubated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting assay | Plasmodium falciparum | 5 | organism-based format | Scientific Literature | ||
| 4. | ALA4185220 | F | Antitrypanosomal activity against Trypanosoma brucei brucei measured after 22 hrs by fluorescence-based Alamar blue viability assay | Trypanosoma brucei brucei | 4 | organism-based format | Scientific Literature | ||
| 5. | ALA4185223 | T | Selectivity index, ratio of IC50 for human NFF cells to IC50 for Trypanosoma brucei brucei | 1 | assay format | Scientific Literature | |||
| 6. | ALA4185224 | T | Selectivity index, ratio of IC50 for HEK293 cells to IC50 for Trypanosoma brucei brucei | 1 | assay format | Scientific Literature | |||
| 7. | ALA4185246 | A | Cytotoxicity against human NFF cells after 72 hrs by SRB assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA4185247 | A | Cytotoxicity against HEK293 cells after 48 hrs by resazurin assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4185248 | T | Selectivity index, ratio of IC50 for human NFF cells to IC50 for Plasmodium falciparum | 5 | assay format | Scientific Literature | |||
| 10. | ALA4185249 | T | Selectivity index, ratio of IC50 for HEK293 cells to IC50 for Plasmodium falciparum | 3 | assay format | Scientific Literature | |||
| 11. | ALA4255997 | F | Reactivation of latent HIV1 infected in human U1 cells assessed as increase in p24 production after 48 hrs by ELISA | Human immunodeficiency virus 1 | 9 | organism-based format | Scientific Literature | ||
| 12. | ALA4255998 | F | Reactivation of latent HIV1 infected in human U1 cells assessed as increase in p24 production after 48 hrs by ELISA relative to vorinostat | Human immunodeficiency virus 1 | 9 | organism-based format | Scientific Literature | ||
| 13. | ALA4255999 | A | Cytotoxicity against human U937 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 14. | ALA4256000 | T | Selectivity index, ratio of CC50 for human U937 cells to EC50 for reactivation of latent HIV1 infected in human U1 cells | 8 | cell-based format | Scientific Literature | |||
| 15. | ALA4268544 | F | Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method | Plasmodium falciparum | 4 | organism-based format | Scientific Literature | ||
| 16. | ALA4268545 | F | Antimalarial activity against Plasmodium falciparum Dd2 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method | Plasmodium falciparum | 4 | organism-based format | Scientific Literature | ||
| 17. | ALA4268546 | A | Cytotoxicity against human NFF cells after 72 hrs by sulforhodamine B assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 18. | ALA4268547 | A | Cytotoxicity against HEK293 cells after 48 hrs by resazurin dye based assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 19. | ALA4268548 | T | Selectivity index, ratio of IC50 for human NFF cells to IC50 for Plasmodium falciparum 3D7 infected in human erythrocytes | 4 | cell-based format | Scientific Literature | |||
| 20. | ALA4268549 | T | Selectivity index, ratio of IC50 for human NFF cells to IC50 for Plasmodium falciparum Dd2 infected in human erythrocytes | 4 | cell-based format | Scientific Literature |
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