| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3365483 | F | Antileishmanial activity against promastigote form of Leishmania infantum MCAN/ES/96/BCN150 after 48 hrs by resazurin fluorescence assay | Leishmania infantum | 6 | ALA3351529 | organism-based format | Scientific Literature | |
| 2. | ALA3365484 | F | Antileishmanial activity against promastigote form of Leishmania amazonensis MHOM/Br/79/Maria after 48 hrs by resazurin fluorescence assay | Leishmania amazonensis | 6 | ALA3351529 | organism-based format | Scientific Literature | |
| 3. | ALA3365485 | F | Antileishmanial activity against promastigote form of Leishmania braziliensis 2903 after 48 hrs by resazurin fluorescence assay | Leishmania braziliensis | 6 | ALA3351529 | organism-based format | Scientific Literature | |
| 4. | ALA3365486 | F | Antileishmanial activity against promastigote form of Leishmania guyanensis 141/93 after 48 hrs by resazurin fluorescence assay | Leishmania guyanensis | 6 | ALA3351529 | organism-based format | Scientific Literature | |
| 5. | ALA3365487 | A | Cytotoxicity against mouse J774 cells assessed as reduction in cell viability after 24 hrs by resazurin fluorescence assay | Mus musculus | 6 | ALA3351529 | cell-based format | Scientific Literature | |
| 6. | ALA3365488 | F | Selectivity index, ratio of CC50 for mouse J774 cells to IC50 for promastigote form of Leishmania infantum MCAN/ES/96/BCN150 | 5 | ALA3351529 | cell-based format | Scientific Literature | ||
| 7. | ALA3365489 | F | Selectivity index, ratio of CC50 for mouse J774 cells to IC50 for promastigote form of Leishmania amazonensis MHOM/Br/79/Maria | 5 | ALA3351529 | cell-based format | Scientific Literature | ||
| 8. | ALA3365490 | F | Selectivity index, ratio of CC50 for mouse J774 cells to IC50 for promastigote form of Leishmania braziliensis 2903 | 6 | ALA3351529 | cell-based format | Scientific Literature | ||
| 9. | ALA3365491 | F | Selectivity index, ratio of CC50 for mouse J774 cells to IC50 for promastigote form of Leishmania guyanensis 141/93 | 6 | ALA3351529 | cell-based format | Scientific Literature | ||
| 10. | ALA3365492 | F | Antileishmanial activity against amastigote form of Leishmania infantum MCAN/ES/96/BCN150 infected in mouse J774 cells assessed as reduction in intracellular amastigotes compound treated for 48 hrs followed by 3 days incubation for transformation by resazurin fluorescence assay | Leishmania infantum | 3 | ALA3351529 | organism-based format | Scientific Literature | |
| 11. | ALA3365493 | F | Selectivity index, ratio of CC50 for mouse J774 cells to IC50 for amastigote form of Leishmania infantum MCAN/ES/96/BCN150 infected in mouse J774 cells | 3 | ALA3351529 | cell-based format | Scientific Literature | ||
| 12. | ALA3365494 | F | Antileishmanial activity against amastigote form of Leishmania amazonensis MHOM/Br/79/Maria infected in mouse J774 cells assessed as reduction in intracellular amastigotes compound treated for 48 hrs followed by 3 days incubation for transformation by resazurin fluorescence assay | Leishmania amazonensis | 3 | ALA3351529 | organism-based format | Scientific Literature | |
| 13. | ALA3365496 | F | Antileishmancidal activity against amastigote form of Leishmania infantum MCAN/ES/96/BCN150 infected in BALB/c mouse assessed as reduction of parasite burden in spleen at 5 mg/kg, ip qd for 5 consecutive days starting 21 days post infection measured after 7 days relative to untreated control | Leishmania infantum | 2 | ALA3351529 | organism-based format | Scientific Literature | |
| 14. | ALA3365497 | F | Antileishmancidal activity against amastigote form of Leishmania infantum MCAN/ES/96/BCN150 infected in BALB/c mouse assessed as reduction of parasite burden in liver at 5 mg/kg, ip qd for 5 consecutive days starting 21 days post infection measured after 7 days relative to untreated control | Leishmania infantum | 2 | ALA3351529 | organism-based format | Scientific Literature | |
| 15. | ALA3365500 | B | Binding affinity to calf thymus DNA assessed as hypochromic effect at DNA-compound ratio of 3 by UV-visible titration method | Bos taurus | 2 | ALA3351529 | nucleic acid format | Scientific Literature | |
| 16. | ALA3365501 | B | Binding affinity to calf thymus DNA by UV-visible titration method | Bos taurus | 2 | ALA3351529 | nucleic acid format | Scientific Literature | |
| 17. | ALA3365503 | B | Effect on calf thymus DNA viscosity at 1 to 10 uM | Bos taurus | 2 | ALA3351529 | assay format | Scientific Literature | |
| 18. | ALA3365504 | A | Binding affinity to bovine serum albumin after 10 mins by fluorimetric titration method | Bos taurus | 2 | ALA3351529 | single protein format | Scientific Literature | |
| 19. | ALA3365505 | A | Binding affinity to bovine serum albumin assessed as quenching constant after 10 mins by Stern-Volmer plot method | Bos taurus | 2 | ALA3351529 | single protein format | Scientific Literature | |
| 20. | ALA3365506 | A | Binding affinity to bovine serum albumin at 2.6 x 10'-6 M by UV absorption spectroscopy | Bos taurus | 2 | ALA3351529 | single protein format | Scientific Literature |
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