# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3376866 | F | Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay | Homo sapiens | 26 | ALA3352485 | cell-based format | Scientific Literature | |
2. | ALA3376867 | F | Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay | Rattus norvegicus | 26 | ALA3352485 | cell-based format | Scientific Literature | |
3. | ALA3376869 | B | Displacement of radioligand from human KISS1R transfected in CHO cells | Homo sapiens | 26 | ALA3352485 | cell-based format | Scientific Literature | |
4. | ALA3376870 | B | Displacement of radioligand from rat KISS1R transfected in CHO cells | Rattus norvegicus | 26 | ALA3352485 | cell-based format | Scientific Literature | |
5. | ALA3376873 | F | Testosterone-suppressive activity in Crl:CD(SD) rat assessed as number of animal with plasma testosterone level below the limit of detection at 0.1 nmol/hr, sc through osmotic pumps measured after 6 days by RIA | Rattus norvegicus | 16 | ALA3352485 | organism-based format | Scientific Literature | |
6. | ALA3376874 | P | Stability of the compound in aqueous solution (JP1) assessed as residual ratio at pH 1.2 up to 1 week by HPLC analysis relative to initial level | 6 | ALA3352485 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA3376875 | P | Stability of the compound in aqueous solution assessed as residual ratio at pH 3 up to 1 week by HPLC analysis relative to initial level | 6 | ALA3352485 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA3376876 | P | Stability of the compound in aqueous solution assessed as residual ratio at pH 5 up to 1 week by HPLC analysis relative to initial level | 6 | ALA3352485 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA3376877 | P | Stability of the compound in aqueous solution assessed as residual ratio at pH 7 up to 1 week by HPLC analysis relative to initial level | 6 | ALA3352485 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA3376878 | P | Stability of the compound in aqueous solution (JP1) assessed as residual ratio at pH 1.2 up to 2 weeks by HPLC analysis relative to initial level | 6 | ALA3352485 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA3376879 | P | Stability of the compound in aqueous solution assessed as residual ratio at pH 3 up to 2 weeks by HPLC analysis relative to initial level | 6 | ALA3352485 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA3376880 | P | Stability of the compound in aqueous solution assessed as residual ratio at pH 5 up to 2 weeks by HPLC analysis relative to initial level | 6 | ALA3352485 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA3376881 | P | Stability of the compound in aqueous solution assessed as residual ratio at pH 7 up to 2 weeks by HPLC analysis relative to initial level | 6 | ALA3352485 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA3376882 | F | Testosterone-suppressive activity in Crl:CD(SD) rat assessed as number of animal with plasma testosterone level below the limit of detection at 0.05 mol/hr, sc through osmotic pumps measured after 6 days by RIA | Rattus norvegicus | 9 | ALA3352485 | organism-based format | Scientific Literature | |
15. | ALA3376883 | F | Testosterone-suppressive activity in Crl:CD(SD) rat assessed as number of animal with plasma testosterone level below the limit of detection at 0.03 mol/hr, sc through osmotic pumps measured after 6 days by RIA | Rattus norvegicus | 9 | ALA3352485 | organism-based format | Scientific Literature | |
16. | ALA3376884 | F | Testosterone-suppressive activity in Crl:CD(SD) rat assessed as number of animal with plasma testosterone level below the limit of detection at 0.01 mol/hr, sc through osmotic pumps measured after 6 days by RIA | Rattus norvegicus | 9 | ALA3352485 | organism-based format | Scientific Literature | |
17. | ALA3376885 | A | Cmin in Sprague-Dawley rat at 1 mg/kg, iv after 5 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA3352485 | organism-based format | Scientific Literature | |
18. | ALA3376886 | A | AUC (0 to 24 hrs) in Sprague-Dawley rat at 1 mg/kg, iv after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA3352485 | organism-based format | Scientific Literature | |
19. | ALA3376887 | A | Mean residence time in Sprague-Dawley rat at 1 mg/kg, iv after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA3352485 | organism-based format | Scientific Literature | |
20. | ALA3376888 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA3352485 | organism-based format | Scientific Literature |