# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3368735 | F | Cytotoxicity against human NB4 cells assessed as reduction in cell viability after 72 hrs by MTS assay | Homo sapiens | 51 | cell-based format | Scientific Literature | ||
2. | ALA3368736 | F | Cytotoxicity against human NB4-R1 cells assessed as reduction in cell viability after 72 hrs by MTS assay | Homo sapiens | 51 | cell-based format | Scientific Literature | ||
3. | ALA3368737 | P | Hydrolytic stability of the compound assessed as drug degradation at pH 7.4, 25 degC measured over 75 hrs | 4 | small-molecule physicochemical format | Scientific Literature | |||
4. | ALA3368738 | F | Induction of apoptosis in human NB4 cells assessed as cleavage of caspase 9 after 48 hrs by Western blotting | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
5. | ALA3368740 | F | Induction of apoptosis in human NB4 cells assessed as cleavage of caspase 3 at 1 to 5 times IC50 after 48 hrs by Western blotting | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
6. | ALA3368741 | F | Induction of apoptosis in human NB4 cells assessed as increase in cleaved PARP level at 1 to 5 times IC50 after 48 hrs by Western blotting | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
7. | ALA3368742 | F | Induction of ER stress-mediated apoptosis in human NB4 cells at 25 to 250 nM after 48 hrs by annexin V and propidium iodide staining-based flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA3368743 | F | Induction of ER stress-mediated apoptosis in human NB4 cells assessed as misfolding/fragmentation of N-CoR at 2.5 to 50 nM after 48 hrs by Western blotting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA3368744 | F | Induction of ER stress-mediated apoptosis in human NB4 cell extract assessed as cytoplasmic localization of N-CoR at 2.5 to 25 nM after 48 hrs by immunofluorescence imaging | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA3368745 | F | Induction of ER stress-mediated UPR signaling pathway in human NB4 cell extract assessed as increase in chaperone proteins PDI level at 250 nM after 24 to 48 hrs by Western blotting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA3368746 | F | Induction of ER stress-mediated UPR signaling pathway in human NB4 cell extract assessed as increase in chaperone proteins GRP78 level at 250 nM after 24 to 48 hrs by Western blotting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA3370125 | F | Induction of ER stress-mediated UPR signaling pathway in human NB4 cell extract assessed as increase in chaperone proteins HSP60 level at 250 nM after 24 to 48 hrs by Western blotting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA3370132 | F | Induction of ER stress-mediated UPR signaling pathway in human NB4 cell extract assessed as increase in phosphorylated PERK level at growth inhibitory IC50 by Western blotting | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
14. | ALA3370133 | F | Induction of ER stress-mediated UPR signaling pathway in human NB4 cell extract assessed as increase in phosphorylated elF2alpha level at growth inhibitory IC50 by Western blotting | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
15. | ALA3370134 | F | Induction of ER stress-mediated UPR signaling pathway in human NB4 cell extract assessed as increase in phosphorylated GADD34 level at growth inhibitory IC50 by Western blotting | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
16. | ALA3370135 | F | Induction of ER stress-mediated UPR signaling pathway in human NB4 cell extract assessed as increase in phosphorylated state of ASK1 at growth inhibitory IC50 after 24 to 48 hrs by Western blotting | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
17. | ALA3370136 | F | Induction of ER stress-mediated UPR signaling pathway in human NB4 cell extract assessed as increase in phosphorylated state of p54/46 JNK at growth inhibitory IC50 after 24 to 48 hrs by Western blotting | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
18. | ALA3370138 | F | Induction of ER stress-mediated apoptosis in human NB4 cells assessed as upregulation of SEC63 gene expression at 50 nM after 48 hrs by microarray analysis relative to DMSO-treated control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
19. | ALA3370139 | F | Induction of ER stress-mediated apoptosis in human NB4 cells assessed as upregulation of SEC62 gene expression at 50 nM after 48 hrs by microarray analysis relative to DMSO-treated control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
20. | ALA3370140 | F | Induction of ER stress-mediated apoptosis in human NB4 cells assessed as upregulation of STT3A gene expression at 50 nM after 48 hrs by microarray analysis relative to DMSO-treated control | Homo sapiens | 1 | cell-based format | Scientific Literature |