# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3367600 | B | Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed as inhibition of SRC1 co-activator peptide recruitment after 3 hrs by TR-FRET analysis | Homo sapiens | 27 | ALA3352759 | assay format | Scientific Literature | |
2. | ALA3367601 | B | Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed as inhibition of SRC1 co-activator peptide recruitment after 3 hrs by TR-FRET analysis relative to apo-RORc ligand binding domain | Homo sapiens | 24 | ALA3352759 | assay format | Scientific Literature | |
3. | ALA3367602 | P | Aqueous kinetic solubility of the compound in PBS buffer at pH 7.4 after 24 hrs | 27 | ALA3352759 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA3367603 | B | Agonist activity at GAL4-fused human RORc expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay | Homo sapiens | 5 | ALA3352759 | cell-based format | Scientific Literature | |
5. | ALA3367604 | B | Agonist activity at GAL4-fused human RORb expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay | Homo sapiens | 5 | ALA3352759 | cell-based format | Scientific Literature | |
6. | ALA3367605 | B | Inverse agonist activity at GAL4-fused human RORa expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay | Homo sapiens | 5 | ALA3352759 | cell-based format | Scientific Literature | |
7. | ALA3367606 | B | Agonist activity at GAL4-fused human FXR expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay | Homo sapiens | 5 | ALA3352759 | cell-based format | Scientific Literature | |
8. | ALA3367607 | B | Agonist activity at GAL4-fused human LXRalpha expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay | Homo sapiens | 5 | ALA3352759 | cell-based format | Scientific Literature | |
9. | ALA3367608 | B | Agonist activity at GAL4-fused human LXRbeta expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay | Homo sapiens | 5 | ALA3352759 | cell-based format | Scientific Literature | |
10. | ALA3367609 | B | Agonist activity at GAL4-fused human PXR expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay | Homo sapiens | 5 | ALA3352759 | cell-based format | Scientific Literature | |
11. | ALA3367610 | F | Antiinflammatory activity in human PBMC assessed as inhibition of IL-17 production after 48 hrs by Sandwich ELISA | Homo sapiens | 3 | ALA3352759 | cell-based format | Scientific Literature | |
12. | ALA3367611 | F | Antiinflammatory activity in human PBMC assessed as inhibition of IL-17 production after 48 hrs by Sandwich ELISA relative to control | Homo sapiens | 3 | ALA3352759 | cell-based format | Scientific Literature | |
13. | ALA3367612 | F | Inhibition of IFNgamma production in human PBMC after 48 hrs by Sandwich ELISA | Homo sapiens | 3 | ALA3352759 | cell-based format | Scientific Literature | |
14. | ALA3367613 | A | Cytotoxicity against human PBMC after 48 hrs by CellTiter-Glo assay | Homo sapiens | 3 | ALA3352759 | cell-based format | Scientific Literature | |
15. | ALA3367614 | A | Fraction unbound in human plasma after 4 hrs by LC-MS/MS analysis | Homo sapiens | 2 | ALA3352759 | cell-free format | Scientific Literature | |
16. | ALA3367615 | A | Fraction unbound in rat plasma after 4 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA3352759 | cell-free format | Scientific Literature | |
17. | ALA3367616 | A | Apparent permeability from apical to basolateral side of MDCK cells at 2 uM by LC-MS/MS analysis | Canis lupus familiaris | 2 | ALA3352759 | cell-based format | Scientific Literature | |
18. | ALA3367617 | A | Apparent permeability from basolateral to apical side of MDCK cells at 2 uM by LC-MS/MS analysis | Canis lupus familiaris | 2 | ALA3352759 | cell-based format | Scientific Literature | |
19. | ALA3367618 | A | Inhibition of CYP3A4 (unknown origin) at 10 uM | Homo sapiens | 1 | ALA3352759 | single protein format | Scientific Literature | |
20. | ALA3367619 | A | Inhibition of CYP2C9 (unknown origin) at 10 uM | Homo sapiens | 1 | ALA3352759 | single protein format | Scientific Literature |