# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3364949 | Binding | Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein-labeled GK measured after 2 to 4 hrs by AlphaScreen assay | Homo sapiens | 45 | ALA3352455 | single protein format | Scientific Literature | |
2. | ALA3364950 | Binding | Induction of GK translocation from nucleus to cytoplasm of mouse hepatocytes preincubated for 20 mins followed by glucose challenge measured after 40 mins by Hoechst 33342 staining-based assay | Mus musculus | 40 | ALA3352455 | cell-based format | Scientific Literature | |
3. | ALA3364951 | ADME | Intrinsic clearance in human liver microsomes at 1 uM after 30 mins in presence of NADPH | Homo sapiens | 45 | ALA3352455 | assay format | Scientific Literature | |
4. | ALA3364952 | ADME | Intrinsic clearance in rat liver microsomes at 1 uM after 30 mins in presence of NADPH | Rattus norvegicus | 45 | ALA3352455 | assay format | Scientific Literature | |
5. | ALA3364953 | ADME | Clearance in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 2 | ALA3352455 | organism-based format | Scientific Literature | |
6. | ALA3364954 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 2 | ALA3352455 | organism-based format | Scientific Literature | |
7. | ALA3364955 | ADME | Mean residence time in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 2 | ALA3352455 | organism-based format | Scientific Literature | |
8. | ALA3369157 | ADME | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg | Rattus norvegicus | 2 | ALA3352455 | organism-based format | Scientific Literature | |
9. | ALA3369158 | ADME | AUC in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 2 | ALA3352455 | organism-based format | Scientific Literature | |
10. | ALA3369159 | ADME | Fraction unbound in Sprague-Dawley rat plasma | Rattus norvegicus | 2 | ALA3352455 | cell-free format | Scientific Literature | |
11. | ALA3369164 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 2 | ALA3352455 | single protein format | Scientific Literature | |
12. | ALA3369165 | ADME | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 2 | ALA3352455 | single protein format | Scientific Literature |