# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3363923 | B | Inhibition of NOD1 (unknown origin) expressed in HEK293T cells coexpressing NF-kappaB driven luciferase reporter gene by HTS primary assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
2. | ALA4710741 | B | Antagonist activity at recombinant human NOD1 expressed in HEK293 cells assessed as inhibition of C12-iE-DAP-induced IL8 release measured after 24 hrs by HTRF assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
3. | ALA4710742 | B | Antagonist activity at recombinant human NOD2 expressed in HEK293 cells assessed as inhibition of MDP-induced IL8 release measured after 24 hrs by HTRF assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4767802 | A | Cytotoxicity against human HEK293 cells expressing human NOD1 assessed as reduction in metabolic activity at 20 uM incubated for 18 hrs by MTS assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
5. | ALA4767803 | A | Cytotoxicity against human HEK293 cells expressing human NOD2 assessed as reduction in metabolic activity at 20 uM incubated for 18 hrs by MTS assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
6. | ALA4767804 | B | Antagonist activity at human NOD1 expressed in HEK293 cells assessed as reduction in C12-iE-DAP-induced NF-kappaB activation at 10 uM preincubated for 1 hr followed by C12-iE-DAP stimulation and measured after 18 hrs by SEAP reporter gene based spectrophotometric analysis | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
7. | ALA4767805 | B | Antagonist activity at human NOD2 expressed in HEK293 cells assessed as reduction in MDP-induced NF-kappaB activation at 10 uM preincubated for 1 hr followed by MDP stimulation and measured after 18 hrs by SEAP reporter gene based spectrophotometric analysis | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
8. | ALA4767806 | B | Antagonist activity at human NOD1 expressed in HEK293 cells assessed as reduction in C12-iE-DAP-induced NF-kappaB activation preincubated for 1 hr followed by C12-iE-DAP stimulation and measured after 18 hrs by SEAP reporter gene based spectrophotometric analysis | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
9. | ALA4767807 | B | Antagonist activity at human NOD2 expressed in HEK293 cells assessed as reduction in MDP-induced NF-kappaB activation preincubated for 1 hr followed by MDP stimulation and measured after 18 hrs by SEAP reporter gene based spectrophotometric analysis | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
10. | ALA4767808 | B | Selectivity index, ratio of IC50 for antagonist activity at human NOD1 expressed in HEK293 cells assessed as reduction in C12-iEE-DAP induced NF-kappaB activation preincubated for 1 hr followed by C12-iE-DAP stimulation and measured after 18 hrs by SEAP reporter gene based spectrophotometric analysis to IC50 for antagonist activity at human NOD2 cells expressed in HEK293 cells assessed as reduction in MDP induced NF-kappaB activation preincubated for 1 hr followed by MDPA stimulation and measured after 18 hrs by SEAP reporter gene based spectrophotometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA4767813 | B | Antagonist activity at NOD2 in human THP-1 cells assessed as reduction in MDP-induced IL-8 secretion at 20 uM preincubated for 1 hr followed by MDP stimulation and measured after 20 hrs by ELISA | Homo sapiens | 4 | cell-based format | Scientific Literature |