# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3370201 | Functional | Antiviral activity against JC polyomavirus Mad1-SVEdelta infected in SVG-A cells assessed as reduction in viral infectivity pre-incubated for 0.5 hrs with compound before viral infection for 72 hrs by flow cytometry | JC polyomavirus | 2 | ALA3351579 | cell-based format | Scientific Literature | |
2. | ALA3370202 | Functional | Antiviral activity against JC polyomavirus Mad1-SVEdelta infected in SVG-A cells assessed as viral infectivity level pre-incubated for 0.5 hrs with 25 uM compound before viral infection for 72 hrs by flow cytometry relative to DMSO control | JC polyomavirus | 38 | ALA3351579 | cell-based format | Scientific Literature | |
3. | ALA3370203 | Functional | Antiviral activity against HPV16 pseudovirus expressing HcRed reporter infected in HeLa-M cells assessed as reduction in viral infectivity pre-incubated for 0.5 hrs with compound before viral infection for 72 hrs by flow cytometry | Human papillomavirus type 16 | 2 | ALA3351579 | organism-based format | Scientific Literature | |
4. | ALA3370204 | Functional | Potency index, ratio of IC50 for Retro-2(cycl) to IC50 for test compound against JC polyomavirus Mad1-SVEdelta infected in SVG-A cells assessed as reduction in viral infectivity pre-incubated for 0.5 hrs with compound before viral infection for 72 hrs by flow cytometry | JC polyomavirus | 1 | ALA3351579 | cell-based format | Scientific Literature | |
5. | ALA3370205 | Functional | Inhibition of retrograde transport of JC polyomavirus Mad1-SVEdelta infected in SVG-A cells assessed as reduction in co-localization of viral capsid protein VP1 and ER protein PDI pre-incubated for 0.5 hrs with compound before viral infection for 1 hr followed by incubation with compound at 0.05 mM for 8 hrs by proximity ligation assay | JC polyomavirus | 1 | ALA3351579 | cell-based format | Scientific Literature | |
6. | ALA3370206 | Functional | Inhibition of retrograde transport of HPV16 pseudovirus expressing HcRed reporter infected in SVG-A cells assessed as reduction in co-localization of viral capsid protein L1 and golgi protein TGN46 pre-incubated for 0.5 hrs with compound before viral infection for 1 hr followed by incubation with compound at 0.05 mM for 16 hrs by proximity ligation assay | Human papillomavirus type 16 | 1 | ALA3351579 | organism-based format | Scientific Literature |