# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3370046 | Functional | Antiplasmodial activity against schizont blood stage Plasmodium falciparum | Plasmodium falciparum | 14 | ALA3352748 | organism-based format | Scientific Literature | |
2. | ALA3370047 | Functional | Antiplasmodial activity against blood stage schizont Plasmodium yoelii | Plasmodium yoelii | 14 | ALA3352748 | organism-based format | Scientific Literature | |
3. | ALA3370048 | Functional | Antiplasmodial activity against schizont liver stage Plasmodium cynomolgi | Plasmodium cynomolgi | 6 | ALA3352748 | organism-based format | Scientific Literature | |
4. | ALA3370049 | Functional | Antiplasmodial activity against hypnozoite liver stage Plasmodium cynomolgi | Plasmodium cynomolgi | 8 | ALA3352748 | organism-based format | Scientific Literature | |
5. | ALA3370050 | Physicochemical | Solubility of the compound at pH 6.8 by HT-equilibrium solubility assay | 5 | ALA3352748 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA3370051 | ADME | Hepatic extraction ratio in mouse liver microsomes by LC/MS analysis | Mus musculus | 4 | ALA3352748 | assay format | Scientific Literature | |
7. | ALA3370052 | ADME | Half life in mouse liver microsomes by LC/MS analysis | Mus musculus | 4 | ALA3352748 | assay format | Scientific Literature | |
8. | ALA3370053 | ADME | Cmax in mouse at 20 mg/kg, po | Mus musculus | 4 | ALA3352748 | organism-based format | Scientific Literature | |
9. | ALA3370054 | ADME | Tmax in mouse at 20 mg/kg, po | Mus musculus | 4 | ALA3352748 | organism-based format | Scientific Literature | |
10. | ALA3370055 | ADME | AUC in mouse at 20 mg/kg, po | Mus musculus | 4 | ALA3352748 | organism-based format | Scientific Literature | |
11. | ALA3370056 | ADME | Half life in mouse at 20 mg/kg, po | Mus musculus | 4 | ALA3352748 | organism-based format | Scientific Literature | |
12. | ALA3370057 | ADME | Oral bioavailability in mouse at 20 mg/kg | Mus musculus | 4 | ALA3352748 | organism-based format | Scientific Literature | |
13. | ALA3370058 | ADME | Volume of distribution at steady state in mouse at 5 mg/kg, iv | Mus musculus | 4 | ALA3352748 | organism-based format | Scientific Literature | |
14. | ALA3370059 | ADME | Clearance in mouse at 5 mg/kg, iv | Mus musculus | 4 | ALA3352748 | organism-based format | Scientific Literature | |
15. | ALA3370060 | ADME | Half life in mouse at 5 mg/kg, iv | Mus musculus | 4 | ALA3352748 | organism-based format | Scientific Literature | |
16. | ALA4125212 | Binding | Inhibition of Plasmodium vivax full length PI4Kbeta after 30 mins by fluorescence-based assay | Plasmodium vivax | 5 | ALA4118268 | assay format | Scientific Literature | |
17. | ALA4683362 | Functional | Antimalarial activity against mefloquine/chloroquine/pyrimethamine resistant Plasmodium falciparum Dd2 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | Plasmodium falciparum | 2 | ALA4680147 | organism-based format | Scientific Literature | |
18. | ALA4683363 | Functional | Antimalarial activity against sulphadoxine-resistant blood stage Plasmodium falciparum 3D7 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | Plasmodium falciparum | 33 | ALA4680147 | organism-based format | Scientific Literature | |
19. | ALA4683364 | Binding | Inhibition of recombinant His-tagged Plasmodium falciparum 3D7 PI4K expressed in baculovirus infected Sf9 cells using PI:PS as substrate incubated for 1 hr in presence of ATP by ADP-Glo kinase assay | Plasmodium falciparum 3D7 | 33 | ALA4680147 | cell-based format | Scientific Literature | |
20. | ALA4683365 | ADME | Inhibition of human PI3Kalpha by ADP-Glo kinase assay | Homo sapiens | 2 | ALA4680147 | single protein format | Scientific Literature |