| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3367119 | Functional | Inhibition of concanavalin A-induced cell proliferation of T cells (unknown origin) at 10 uM after 72 hrs by MTT assay | Not specified | 17 | ALA3351580 | cell-based format | Scientific Literature | |
| 2. | ALA3367120 | Functional | Inhibition of LPS-induced cell proliferation of B cells (unknown origin) at 10 uM after 72 hrs by MTT assay | Not specified | 17 | ALA3351580 | cell-based format | Scientific Literature | |
| 3. | ALA3367121 | Physicochemical | Solubility in water | 16 | ALA3351580 | small-molecule physicochemical format | Scientific Literature | ||
| 4. | ALA3367122 | Functional | Inhibition of LPS-induced IL6 production in human THP1 cells after 24 hrs | Homo sapiens | 17 | ALA3351580 | cell-based format | Scientific Literature | |
| 5. | ALA3367334 | Functional | Inhibition of LPS-induced TNFalpha production in human THP1 cells after 24 hrs | Homo sapiens | 17 | ALA3351580 | cell-based format | Scientific Literature | |
| 6. | ALA3367335 | Functional | Inhibition of LPS-induced IL-1beta production in human THP1 cells at 10 uM after 24 hrs | Homo sapiens | 3 | ALA3351580 | cell-based format | Scientific Literature | |
| 7. | ALA3367336 | Functional | Inhibition of LPS-induced nitric oxide production in human THP1 cells at 10 uM after 24 hrs by Griess assay | Homo sapiens | 3 | ALA3351580 | cell-based format | Scientific Literature | |
| 8. | ALA3367337 | ADME | Cytotoxicity against human THP1 cells after 24 hrs by MTT assay | Homo sapiens | 3 | ALA3351580 | cell-based format | Scientific Literature | |
| 9. | ALA3367338 | ADME | Cytotoxicity against human THP1 cells after 48 hrs by MTT assay | Homo sapiens | 3 | ALA3351580 | cell-based format | Scientific Literature | |
| 10. | ALA3367339 | ADME | Therapeutic index, ratio of cytotoxic IC50 for human THP1 cells by MTT assay to IC50 for inhibition of LPS-induced IL6 production in human THP1 cells | Homo sapiens | 3 | ALA3351580 | cell-based format | Scientific Literature | |
| 11. | ALA3367340 | Functional | Antiinflammatory activity in BALB/c mouse assessed as serum TNFalpha level at 10 mg/kg, po qd for 5 days followed by LPS challenge 1 hr after last compound dose on fifth day and measured 4 hrs post LPS challenge by ELISA method (Rvb = 717 +/- 218 pg/mL) | Mus musculus | 3 | ALA3351580 | organism-based format | Scientific Literature | |
| 12. | ALA3367341 | Functional | Antiinflammatory activity in BALB/c mouse assessed as serum TNFalpha level at 100 mg/kg, po qd for 5 days followed by LPS challenge 1 hr after last compound dose on fifth day and measured 4 hrs post LPS challenge by ELISA method (Rvb = 717 +/- 218 pg/mL) | Mus musculus | 3 | ALA3351580 | organism-based format | Scientific Literature | |
| 13. | ALA3367342 | Functional | Antiinflammatory activity in BALB/c mouse assessed as serum IL6 level at 10 mg/kg, po qd for 5 days followed by LPS challenge 1 hr after last compound dose on fifth day and measured 4 hrs post LPS challenge by ELISA method (Rvb = 410 +/- 95 pg/mL) | Mus musculus | 3 | ALA3351580 | organism-based format | Scientific Literature | |
| 14. | ALA3367343 | Functional | Antiinflammatory activity in BALB/c mouse assessed as serum IL6 level at 100 mg/kg, po qd for 5 days followed by LPS challenge 1 hr after last compound dose on fifth day and measured 4 hrs post LPS challenge by ELISA method (Rvb = 410 +/- 95 pg/mL) | Mus musculus | 3 | ALA3351580 | organism-based format | Scientific Literature | |
| 15. | ALA3367344 | Functional | Antiinflammatory activity in BALB/c mouse assessed as serum nitric oxide level at 10 mg/kg, po qd for 5 days followed by LPS challenge 1 hr after last compound dose on fifth day and measured 4 hrs post LPS challenge by Griess assay (Rvb = 6.95 +/- 1.81 uM) | Mus musculus | 3 | ALA3351580 | organism-based format | Scientific Literature | |
| 16. | ALA3367345 | Functional | Antiinflammatory activity in BALB/c mouse assessed as serum nitric oxide level at 100 mg/kg, po qd for 5 days followed by LPS challenge 1 hr after last compound dose on fifth day and measured 4 hrs post LPS challenge by Griess assay (Rvb = 6.95 +/- 1.81 uM) | Mus musculus | 3 | ALA3351580 | organism-based format | Scientific Literature | |
| 17. | ALA3367346 | Functional | Antiarthritic activity in BALB/c mouse assessed as reduction in SRBC-induced blood IFNgamma level administered orally once daily for 14 days measured 4 hrs post last dose by ELISA method | Mus musculus | 3 | ALA3351580 | organism-based format | Scientific Literature | |
| 18. | ALA3367347 | Functional | Antiarthritic activity in BALB/c mouse assessed as reduction in SRBC-induced blood IL4 level administered orally once daily for 14 days measured 4 hrs post last dose by ELISA method | Mus musculus | 3 | ALA3351580 | organism-based format | Scientific Literature | |
| 19. | ALA3367348 | Functional | Antiarthritic activity in BALB/c mouse assessed as reduction in SRBC-induced blood IL2 level administered orally once daily for 14 days measured 4 hrs post last dose by ELISA method | Mus musculus | 3 | ALA3351580 | organism-based format | Scientific Literature | |
| 20. | ALA3367349 | Functional | Immunosuppressive activity in BALB/c mouse assessed as reduction in SRBC-induced humoral immunity by measuring IgM level at 3 to 30 mg/kg, po administered once daily for 14 days measured 4 hrs post last dose | Mus musculus | 3 | ALA3351580 | organism-based format | Scientific Literature |
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