| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3361506 | B | Inhibition of constitutively activated GST-tagged human MEK1 S218D/S22D (MEK1DD) mutant assessed blocking of increase in bovine MBP kinase activity of recombinant His6-tagged ERK2 using [gamma32P]ATP by liquid scintillation counting method | Homo sapiens | 15 | assay format | Scientific Literature | ||
| 2. | ALA3361507 | B | Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 mins by immunoblotting method | Rattus norvegicus | 15 | organism-based format | Scientific Literature | ||
| 3. | ALA3361508 | B | Inhibition of MEK1 (unknown origin) at 1 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 4. | ALA3361509 | F | Antiproliferative activity against human HT-29 cells after 5 days by WST1 assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA3361510 | F | Antiproliferative activity against human A375 cells after 5 days by WST1 assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA3361511 | F | Antiproliferative activity against human A549 cells after 5 days by WST1 assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA3361512 | F | Antiproliferative activity against human HCT116 cells after 5 days by WST1 assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA3361513 | B | Potency index, ratio of IC50 for PD98059 to IC50 for test compound against constitutively activated GST-tagged human MEK1 S218D/S22D (MEK1DD) mutant | Homo sapiens | 1 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!