Antimalarial activity against tightly synchronized Plasmodium falciparum K1 assessed as parasite stage accumulation index at early ring stages at 10 uM treated at 6 to 30 hrs post-invasion by automated image mining based cytological profiling assay
Antimalarial activity against tightly synchronized Plasmodium falciparum K1 assessed as parasite stage accumulation index at late ring stages at 10 uM treated at 6 to 30 hrs post-invasion by automated image mining based cytological profiling assay
Antimalarial activity against tightly synchronized Plasmodium falciparum K1 assessed as parasite stage accumulation index at trophozoites stages at 10 uM treated at 6 to 30 hrs post-invasion by automated image mining based cytological profiling assay
Antimalarial activity against tightly synchronized Plasmodium falciparum K1 assessed as parasite stage accumulation index at schizonts stages at 10 uM treated at 6 to 30 hrs post-invasion by automated image mining based cytological profiling assay
Stability in human liver microsomes assessed as remaining compound level at 1 uM incubated for 5 mins in presence of NADPH measured after 30 mins by LC/MS/MS method
Stability in mouse liver microsomes assessed as remaining compound level at 1 uM incubated for 5 mins in presence of NADPH measured after 30 mins by LC/MS/MS method
Antimalarial activity against Plasmodium chabaudi infected in BALB/c mouse assessed as reduction in parasitaemia level treated intraperitoneally on day 1 to day 3 post-infection measured on day 4 post-infection by Giemsa staining based light microscopy
Antimalarial activity against Plasmodium chabaudi infected in BALB/c mouse assessed as reduction in accumulation of ring-stage parasites level at 3 to 30 mg/kg, ip treated on day 1 to day 3 post-infection measured on day 4 post-infection by Giemsa staining based light microscopy