| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3378918 | B | Positive allosteric modulation at human alpha7 nACHR expressed in Xenopus oocyte assessed as potentiation of 200 uM ACh-induced current at holding potential of -80 mV by electrophysiology | Homo sapiens | 21 | assay format | Scientific Literature | ||
| 2. | ALA3378919 | B | Positive allosteric modulation at human alpha7 nACHR expressed in Xenopus oocyte assessed as potentiation of 200 uM ACh-induced current at holding potential of -80 mV by electrophysiology relative to control | Homo sapiens | 18 | assay format | Scientific Literature | ||
| 3. | ALA3378921 | B | Positive allosteric modulation at human alpha7 nACHR expressed in Xenopus oocyte assessed as potentiation of ACh-induced current at holding potential of -80 mV measured as ACh EC50 at 1 uM by electrophysiology (Rvb = 176 uM) | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 4. | ALA3378922 | B | Activity at human alpha4beta2 nACHR expressed in Xenopus oocyte assessed as induction of current at holding potential of -80 mV at 10 uM by electrophysiology relative to ACh | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 5. | ALA3378923 | B | Activity at human alpha3beta4 nACHR expressed in Xenopus oocyte assessed as induction of current at holding potential of -80 mV at 10 uM by electrophysiology relative to ACh | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 6. | ALA3378927 | A | Cytotoxicity against HEK293 cells up to 10 uM after 24 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA3378928 | A | Cytotoxicity against Swiss albino mouse postmitotic hippocampal neurons assessed as cell death at 10 uM after 24 hrs by LDH release assay | Mus musculus | 1 | assay format | Scientific Literature | ||
| 8. | ALA3378929 | A | Cytotoxicity against Swiss albino mouse postmitotic hippocampal neurons assessed as cell viability at 10 uM after 24 hrs by MTT assay | Mus musculus | 1 | assay format | Scientific Literature | ||
| 9. | ALA3378930 | A | Effect on Sprague-Dawley rat atrium assessed as force or beating frequency at 0.01 to 100 uM | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 10. | ALA3378931 | A | Effect on Sprague-Dawley rat vas deferens assessed as spontaneous and voltage-stimulated contraction at 0.01 to 100 uM | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 11. | ALA3378932 | A | Effect on Sprague-Dawley rat ileum assessed as peristaltic force or frequency at 0.01 to 100 uM | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 12. | ALA3378933 | A | Effect on Sprague-Dawley rat phrenic-diaphragm muscle at 0.01 to 100 uM | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 13. | ALA3378934 | T | Toxicity in anesthetized Sprague-Dawley rat assessed as reduction of heart rate at 1 ug/kg, iv administered as infusion | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA3378935 | T | Toxicity in anesthetized Sprague-Dawley rat assessed as reduction in blood pressure at 100 ug/kg, iv administered as infusion | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA3378936 | F | Neuroprotective activity against rotenone/oligomycin-A-induced death of mouse HT22 cells assessed as measured as increase in cell viability preincubated at 1 uM after 24 hrs by MTT assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA3378937 | F | Neuroprotective activity against rotenone/oligomycin-A-induced death of mouse HT22 cells assessed as measured as increase in cell viability preincubated at 10 uM after 24 hrs by MTT assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA3378938 | F | Neuroprotective activity against rotenone/oligomycin-A-induced death of mouse HT22 cells assessed as measured as increase in cell viability preincubated at 1 to 10 uM after 24 hrs by MTT assay in presence of alpha-BGT | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA3378940 | F | Analgesic activity in CFA-induced paw inflammation Wistar rat model assessed as latency in response to thermal stimulation at 10 mg/kg, iv administered 24 hrs post challenge measured up to 4 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3378941 | F | Analgesic activity in CFA-induced paw inflammation Wistar rat model assessed as latency in response to mechanical stimulation at 10 mg/kg, iv administered 24 hrs post challenge measured up to 2 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3378942 | F | Increase in learning ability in mouse at 10 ug/kg, ip for 5 days by water maze Morris test | Mus musculus | 1 | organism-based format | Scientific Literature |
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