# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3366940 | Functional | Antitrypanosomal activity against Trypanosoma cruzi Y luc infected in mouse assessed as inhibition of parasitemia at 40 mg/kg, ip bid in 20% Kolliphor administered for 4 consecutive days starting on day 3 of infection measured on day 7 post infection relative to vehicle-treated control | Trypanosoma cruzi | 14 | ALA3352430 | organism-based format | Scientific Literature | |
2. | ALA3366941 | Functional | Antitrypanosomal activity against Trypanosoma cruzi Y luc infected in mouse assessed as inhibition of parasitemia at 25 mg/kg, po bid in 20% Kolliphor administered for 4 consecutive days starting on day 3 of infection measured on day 7 post infection relative to vehicle-treated control | Trypanosoma cruzi | 14 | ALA3352430 | organism-based format | Scientific Literature | |
3. | ALA3366942 | Functional | Antitrypanosomal activity against Trypanosoma cruzi Y luc infected in mouse assessed as inhibition of parasitemia at 50 mg/kg, po bid in 20% Kolliphor administered for 4 consecutive days starting on day 3 of infection measured on day 7 post infection relative to vehicle-treated control | Trypanosoma cruzi | 14 | ALA3352430 | organism-based format | Scientific Literature | |
4. | ALA3366943 | ADME | Half life in human liver microsomes | Homo sapiens | 14 | ALA3352430 | assay format | Scientific Literature | |
5. | ALA3366944 | ADME | Half life in rat liver microsomes | Rattus norvegicus | 14 | ALA3352430 | assay format | Scientific Literature | |
6. | ALA3366945 | ADME | Half life in mouse liver microsomes | Mus musculus | 14 | ALA3352430 | assay format | Scientific Literature | |
7. | ALA3366946 | ADME | Inhibition of CYP1A2 in human liver microsomes at 1 uM | Homo sapiens | 14 | ALA3352430 | assay format | Scientific Literature | |
8. | ALA3366947 | ADME | Inhibition of CYP2C9 in human liver microsomes at 1 uM | Homo sapiens | 14 | ALA3352430 | assay format | Scientific Literature | |
9. | ALA3366948 | ADME | Inhibition of CYP2D6 in human liver microsomes at 1 uM | Homo sapiens | 14 | ALA3352430 | assay format | Scientific Literature | |
10. | ALA3366949 | ADME | Inhibition of CYP3A4 in human liver microsomes at 1 uM | Homo sapiens | 14 | ALA3352430 | assay format | Scientific Literature | |
11. | ALA3366950 | Functional | Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in mouse C2C12 cells after 72 hrs by DAPI staining method | Trypanosoma cruzi | 14 | ALA3352430 | organism-based format | Scientific Literature | |
12. | ALA3366951 | ADME | Cytotoxicity against mouse C2C12 cells up to 10 uM | Mus musculus | 14 | ALA3352430 | cell-based format | Scientific Literature | |
13. | ALA3366952 | ADME | Cytotoxicity against mouse cardiomyocytes assessed as growth inhibition after 72 hrs by Cell Titer Glo assay | Mus musculus | 5 | ALA3352430 | assay format | Scientific Literature | |
14. | ALA3366953 | ADME | Cytotoxicity against mouse hepatocytes assessed as growth inhibition after 72 hrs by Cell Titer Glo assay | Mus musculus | 5 | ALA3352430 | cell-based format | Scientific Literature | |
15. | ALA3366954 | Unassigned | Selectivity index, ratio of EC50 for mouse cardiomyocytes to EC50 for Trypanosoma cruzi amastigotes infected in mouse C2C12 cells | 5 | ALA3352430 | cell-based format | Scientific Literature | ||
16. | ALA3366955 | Unassigned | Selectivity index, ratio of EC50 for mouse hepatocytes to EC50 for Trypanosoma cruzi amastigotes infected in mouse C2C12 cells | 5 | ALA3352430 | cell-based format | Scientific Literature | ||
17. | ALA3366956 | ADME | Half life in mouse at 50 mg/kg, po in 20% Kolliphor | Mus musculus | 6 | ALA3352430 | organism-based format | Scientific Literature | |
18. | ALA3366957 | ADME | Half life in mouse at 50 mg/kg, po in 20% HP-beta-CD | Mus musculus | 5 | ALA3352430 | organism-based format | Scientific Literature | |
19. | ALA3366958 | ADME | Tmax in mouse at 50 mg/kg, po in 20% Kolliphor | Mus musculus | 6 | ALA3352430 | organism-based format | Scientific Literature | |
20. | ALA3366959 | ADME | Tmax in mouse at 50 mg/kg, po in 20% HP-beta-CD | Mus musculus | 5 | ALA3352430 | organism-based format | Scientific Literature |