| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3377189 | F | Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgammaS binding assay | Homo sapiens | 48 | ALA3351921 | cell-based format | Scientific Literature | |
| 2. | ALA3377190 | B | Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change after 10 mins by fluorescence assay | Homo sapiens | 1 | ALA3351921 | single protein format | Scientific Literature | |
| 3. | ALA3377191 | F | Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells assessed as dissociation half-life at 5 to 10 times IC50 after 2 hrs by radio-labelled [35S]-GTPgammaS binding assay | Homo sapiens | 48 | ALA3351921 | cell-based format | Scientific Literature | |
| 4. | ALA3377192 | B | Inhibition of at prostanoid DP1 receptor (unknown origin) at 10 uM | Homo sapiens | 11 | ALA3351921 | single protein format | Scientific Literature | |
| 5. | ALA3377193 | B | Inhibition of at prostanoid TP receptor (unknown origin) at 10 uM | Homo sapiens | 11 | ALA3351921 | single protein format | Scientific Literature | |
| 6. | ALA3377194 | P | Dissociation constant, pKa of the compound by potentiometric method | 8 | ALA3351921 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA3377195 | F | Antagonist activity at CRTh2 (unknown origin) stably expressed in CHO.K1 cells preincubated for 1 hr by radio-labelled [35S]-GTPgammaS binding assay in presence of 4% HSA | Homo sapiens | 1 | ALA3351921 | cell-based format | Scientific Literature | |
| 8. | ALA3377196 | A | Apparent permeability across apical to basolateral side of human Caco2 cells at pH 7.4 | Homo sapiens | 19 | ALA3351921 | cell-based format | Scientific Literature | |
| 9. | ALA3377197 | A | Apparent permeability across basolateral to apical side of human Caco2 cells at pH 7.4 | Homo sapiens | 1 | ALA3351921 | cell-based format | Scientific Literature | |
| 10. | ALA3377198 | P | Aqueous solubility of the compound at pH 1 | 1 | ALA3351921 | small-molecule physicochemical format | Scientific Literature | ||
| 11. | ALA3377199 | P | Aqueous solubility of the compound at pH 7.4 | 1 | ALA3351921 | small-molecule physicochemical format | Scientific Literature | ||
| 12. | ALA3377200 | P | Lipophilicity, log D of the compound by shake-flask method | 1 | ALA3351921 | small-molecule physicochemical format | Scientific Literature | ||
| 13. | ALA3377754 | F | Antagonist activity at CRTh2 (unknown origin) stably expressed in CHO.K1 cells co-mixing the compound and PGD2 by radio-labelled [35S]-GTPgammaS binding assay | Homo sapiens | 3 | ALA3351921 | cell-based format | Scientific Literature | |
| 14. | ALA3377755 | F | Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 15 mins by radio-labelled [35S]-GTPgammaS binding assay | Homo sapiens | 3 | ALA3351921 | cell-based format | Scientific Literature | |
| 15. | ALA3377756 | F | Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 30 mins by radio-labelled [35S]-GTPgammaS binding assay | Homo sapiens | 3 | ALA3351921 | cell-based format | Scientific Literature | |
| 16. | ALA3377757 | F | Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 60 mins by radio-labelled [35S]-GTPgammaS binding assay | Homo sapiens | 3 | ALA3351921 | cell-based format | Scientific Literature | |
| 17. | ALA3377758 | F | Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 120 mins by radio-labelled [35S]-GTPgammaS binding assay | Homo sapiens | 3 | ALA3351921 | cell-based format | Scientific Literature | |
| 18. | ALA3377759 | F | Antagonist activity at CRTh2 (unknown origin) stably expressed in PGD2-stimulated CHO.K1 cells preincubated for 180 mins by radio-labelled [35S]-GTPgammaS binding assay | Homo sapiens | 3 | ALA3351921 | cell-based format | Scientific Literature | |
| 19. | ALA3778970 | B | Displacement of [35S]-GTPgammaS from CRTH2 receptor (unknown origin) expressed in CHOK1 cell membrane after 1 hr by liquid scintillation counter | Homo sapiens | 22 | ALA3774370 | cell-based format | Scientific Literature | |
| 20. | ALA3778972 | B | Antagonist activity at CRTH2 receptor (unknown origin) expressed in CHOK1 cells assessed as dissociation half life measured up to 25 hrs by GTPgammaS assay | Homo sapiens | 26 | ALA3774370 | cell-based format | Scientific Literature |
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