# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3386351 | B | Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay | Homo sapiens | 16 | ALA3351740 | cell-based format | Scientific Literature | |
2. | ALA3386352 | B | Inhibition of HDAC1/2/3 in human HeLa cells assessed as p21 gene expression at 3 uM after 15 hrs by luciferase reporter gene assay relative to SNDX-275 | Homo sapiens | 15 | ALA3351740 | cell-based format | Scientific Literature | |
3. | ALA3386353 | B | Inhibition of HDAC1/2/3 in human HeLa cells assessed as p21 gene expression at 10 uM after 15 hrs by luciferase reporter gene assay relative to SNDX-275 | Homo sapiens | 16 | ALA3351740 | cell-based format | Scientific Literature | |
4. | ALA3386355 | B | Inhibition of HDAC1 (unknown origin) using fluorogenic peptide as substrate by fluorescence assay | Homo sapiens | 4 | ALA3351740 | single protein format | Scientific Literature | |
5. | ALA3386356 | B | Inhibition of HDAC2 (unknown origin) using fluorogenic peptide as substrate by fluorescence assay | Homo sapiens | 4 | ALA3351740 | single protein format | Scientific Literature | |
6. | ALA3386357 | B | Inhibition of HDAC3 (unknown origin) using fluorogenic peptide as substrate by fluorescence assay | Homo sapiens | 4 | ALA3351740 | single protein format | Scientific Literature | |
7. | ALA3386358 | B | Inhibition of HDAC4 (unknown origin) using fluorogenic peptide as substrate by fluorescence assay | Homo sapiens | 4 | ALA3351740 | single protein format | Scientific Literature | |
8. | ALA3386359 | B | Inhibition of HDAC5 (unknown origin) using fluorogenic peptide as substrate by fluorescence assay | Homo sapiens | 4 | ALA3351740 | single protein format | Scientific Literature | |
9. | ALA3386360 | B | Inhibition of HDAC6 (unknown origin) using fluorogenic peptide as substrate by fluorescence assay | Homo sapiens | 4 | ALA3351740 | single protein format | Scientific Literature | |
10. | ALA3386361 | B | Inhibition of HDAC7 (unknown origin) using fluorogenic peptide as substrate by fluorescence assay | Homo sapiens | 4 | ALA3351740 | single protein format | Scientific Literature | |
11. | ALA3386362 | B | Inhibition of HDAC8 (unknown origin) using fluorogenic peptide as substrate by fluorescence assay | Homo sapiens | 4 | ALA3351740 | single protein format | Scientific Literature | |
12. | ALA3386363 | B | Inhibition of HDAC9 (unknown origin) using fluorogenic peptide as substrate by fluorescence assay | Homo sapiens | 4 | ALA3351740 | single protein format | Scientific Literature | |
13. | ALA3386364 | B | Inhibition of HDAC10 (unknown origin) using fluorogenic peptide as substrate by fluorescence assay | Homo sapiens | 4 | ALA3351740 | single protein format | Scientific Literature | |
14. | ALA3386365 | B | Inhibition of HDAC11 (unknown origin) using fluorogenic peptide as substrate by fluorescence assay | Homo sapiens | 4 | ALA3351740 | single protein format | Scientific Literature | |
15. | ALA3386366 | F | Antiproliferative activity against human NCI-H929 cells assessed as growth inhibition after 72 hrs by CCK-8 assay | Homo sapiens | 4 | ALA3351740 | cell-based format | Scientific Literature | |
16. | ALA3386367 | F | Antiproliferative activity against human BE(2)-C cells assessed as growth inhibition after 72 hrs by CCK-8 assay | Homo sapiens | 4 | ALA3351740 | cell-based format | Scientific Literature | |
17. | ALA3386368 | A | Stability in human liver microsomes at 1 uM after 3 to 30 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3351740 | assay format | Scientific Literature | |
18. | ALA3386369 | A | Stability in mouse liver microsomes at 1 uM after 3 to 30 mins by LC-MS/MS analysis | Mus musculus | 1 | ALA3351740 | assay format | Scientific Literature | |
19. | ALA3386966 | A | Cytotoxicity against human BE(2)-C cells at 2 uM after 3 to 9 days by CCK-8 assay | Homo sapiens | 2 | ALA3351740 | cell-based format | Scientific Literature | |
20. | ALA3386967 | F | Induction of cell differentiation in human BE(2)-C cells assessed as increase in acetylated tubulin at 2 to 10 uM after 24 hrs by immunoblot method relative to vehicle-treated control | Homo sapiens | 2 | ALA3351740 | cell-based format | Scientific Literature |