| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3386489 | B | Activation of human TLR4/MD2 complex expressed in HEK293 Blue cells coexpressing CD14 assessed as SEAP secretion at 10 uM after 20 to 24 hrs by SEAPorter assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA3386490 | F | Induction of IL-6 production in TLR4-deficient mouse BMDC at 10 uM by ELISA | Mus musculus | 1 | assay format | Scientific Literature | ||
| 3. | ALA3386491 | B | Activation of human TLR4/MD2 complex expressed in CD14-deficient HEK293 Blue cells assessed as SEAP secretion at 10 uM after 20 to 24 hrs by SEAPorter assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA3386492 | B | Activation of human TLR4 complex expressed in MD2-deficient HEK293 Blue cells coexpressing CD14 assessed as SEAP secretion at 10 uM after 20 to 24 hrs by SEAPorter assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA3386493 | B | Activation of human TLR4/MD2 complex expressed in HEK293 Blue cells coexpressing CD14 assessed as SEAP secretion at 10 uM after 20 to 24 hrs by SEAPorter assay in presence of Rhodobacter sphaeroides LPS | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3386494 | F | Induction of IL-8 expression in human PBMC by ELISA in presence of polymyxin B | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA3386495 | F | Induction of type 1 IFN release in mouse L929-ISRE cells assessed as luciferase release at 10 uM | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA3386496 | F | Induction of CD40 expression in wild type CD11c+ population of mouse BMDC | Mus musculus | 1 | assay format | Scientific Literature | ||
| 9. | ALA3386497 | F | Induction of CD80 expression in wild type CD11c+ population of mouse BMDC | Mus musculus | 1 | assay format | Scientific Literature | ||
| 10. | ALA3386498 | F | Induction of CD86 expression in wild type CD11c+ population of mouse BMDC | Mus musculus | 1 | assay format | Scientific Literature | ||
| 11. | ALA3386499 | F | Induction of CD40 expression in TLR4-deficient CD11c+ population of mouse BMDC | Mus musculus | 1 | assay format | Scientific Literature | ||
| 12. | ALA3386500 | F | Induction of CD80 expression in TLR4-deficient CD11c+ population of mouse BMDC | Mus musculus | 1 | assay format | Scientific Literature | ||
| 13. | ALA3386501 | F | Induction of CD86 expression in TLR4-deficient CD11c+ population of mouse BMDC | Mus musculus | 1 | assay format | Scientific Literature | ||
| 14. | ALA3386502 | F | Induction of CD80 expression in CD11c+ HLA-DR+ population of human PBMC | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA3386503 | F | Induction of CD83 expression in CD11c+ HLA-DR+ population of human PBMC | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA3386504 | B | Activation of human TLR4/MD2 complex in human THP1 cells assessed as induction of NFkappaB activation incubated for 18 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA3386505 | B | Activation of human TLR4/MD2 complex in mouse RAW264.7 cells assessed as induction of NFkappaB activation incubated for 18 hrs | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA3386506 | F | Induction of IL-8 level in human PBMC at < 1 uM by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA3386507 | F | Induction of IL-6 level in mouse BMDC at < 1 uM by ELISA | Mus musculus | 1 | assay format | Scientific Literature | ||
| 20. | ALA3386508 | A | Cytotoxicity against human PBMC at 10 uM after 18 hrs incubation by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!