Inhibition of LPS-induced NO production in C57BL/6 mouse macrophages preincubated with compound for 1 hr before LPS challenge measured after 24 hrs by Griess method
Antiinflammatory activity in Kunming mouse assessed as inhibition of croton oil-induced ear edema at 5 umol/kg, po administered before challenge relative to vehicle-treated control
Antiinflammatory activity in Kunming mouse assessed as inhibition of croton oil-induced ear edema at 10 umol/kg, po administered before challenge relative to vehicle-treated control
Antiinflammatory activity in Kunming mouse assessed as inhibition of croton oil-induced ear edema at 20 umol/kg, po administered before challenge relative to vehicle-treated control
Antiinflammatory activity in specific pathogen-free COPD-like lung inflammation BALB/c mouse model assessed as inhibition of neutrophils at 2 umol/kg/day, po for 35 days measured 24 hrs post last dose relative to vehicle-treated control
Antiinflammatory activity in specific pathogen-free COPD-like lung inflammation BALB/c mouse model assessed as inhibition of white blood cells at 2 umol/kg/day, po for 35 days measured 24 hrs post last dose relative to vehicle-treated control
Antiinflammatory activity in specific pathogen-free COPD-like lung inflammation BALB/c mouse model assessed as inhibition of eosinophils at 2 umol/kg/day, po for 35 days measured 24 hrs post last dose relative to vehicle-treated control
Antiinflammatory activity in specific pathogen-free COPD-like lung inflammation BALB/c mouse model assessed as inhibition of TNFalpha level at 2 umol/kg/day, po for 35 days measured 24 hrs post last dose relative to vehicle-treated control
Antiinflammatory activity in specific pathogen-free COPD-like lung inflammation BALB/c mouse model assessed as inhibition of IL-1beta level at 2 umol/kg/day, po for 35 days measured 24 hrs post last dose relative to vehicle-treated control
Antiinflammatory activity in specific pathogen-free COPD-like lung inflammation BALB/c mouse model assessed as inhibition of IL-6 level at 2 umol/kg/day, po for 35 days measured 24 hrs post last dose relative to vehicle-treated control