# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3384695 | P | Photo-stability assessed as drug degradation exposed to after 230 Jcm'-2 of continuous illumination with 350 to 800 nm light in solutions of 10% CH3OH in pH 7.4 buffer | 2 | ALA3352492 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA3384696 | P | Photo-stability assessed as drug degradation exposed to after 230 Jcm'-2 of continuous illumination with 500 to 800 nm light in solutions of 10% CH3OH in pH 7.4 buffer | 2 | ALA3352492 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA3384697 | P | Lipophilicity, log P of the compound by pH 7.4 at 23 degC by UV-visible spectrophotometry based shake flask method | 4 | ALA3352492 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA3384698 | A | Drug uptake in mouse Colon 26 cells at 0.5 uM in absence of 100 uM verapamil by flow cytometry | Mus musculus | 4 | ALA3352492 | cell-based format | Scientific Literature | |
5. | ALA3384699 | A | Drug uptake in mouse Colon 26 cells at 0.5 uM in presence of 100 uM verapamil by flow cytometry | Mus musculus | 8 | ALA3352492 | cell-based format | Scientific Literature | |
6. | ALA3384702 | F | Photo-toxicity in mouse Colon 26 cells assessed as reduction in cell surviving fraction at 0.5 Jcm'-2 of continuous illumination with 350 to 700 nm light incubated for 48 hrs by sulforhodamine B assay | Mus musculus | 4 | ALA3352492 | cell-based format | Scientific Literature | |
7. | ALA3384703 | F | Photo-toxicity in mouse Colon 26 cells assessed as reduction in cell surviving fraction at 1 Jcm'-2 of continuous illumination with 350 to 700 nm light incubated for 48 hrs by sulforhodamine B assay | Mus musculus | 4 | ALA3352492 | cell-based format | Scientific Literature | |
8. | ALA3384704 | T | Dark toxicity in mouse Colon 26 cells assessed as cell surviving fraction incubated for 48 hrs by sulforhodamine B assay | Mus musculus | 4 | ALA3352492 | cell-based format | Scientific Literature | |
9. | ALA3384705 | T | Selectivity index, ratio of LD50 dark toxicity against mouse Colon 26 cells to EC50 for Photo-toxicity against mouse Colon 26 cells 1 Jcm'-2 of continuous illumination with 350 to 700 nm light | Mus musculus | 4 | ALA3352492 | cell-based format | Scientific Literature | |
10. | ALA3384706 | F | Photo-toxicity in mouse Colon 26 cells assessed as reduction in cell surviving fraction at 0.15 uM at 1 Jcm'-2 of continuous illumination with 350 to 700 nm light incubated for 48 hrs by sulforhodamine B assay | Mus musculus | 2 | ALA3352492 | cell-based format | Scientific Literature | |
11. | ALA3385315 | A | Permeability from apical to basolateral side in MDCK2-MDR1 cells at 5 uM in presence of 4.3 mg/ml BSA and in presence of P-gp inhibitor LSN335984 by mass spectrometry | Canis lupus familiaris | 2 | ALA3352492 | cell-based format | Scientific Literature | |
12. | ALA3385316 | A | Permeability from apical to basolateral side in MDCK2-MDR1 cells at 5 uM in presence of 4.3 mg/ml BSA and in absence of P-gp inhibitor LSN335984 by mass spectrometry | Canis lupus familiaris | 2 | ALA3352492 | cell-based format | Scientific Literature | |
13. | ALA3385317 | A | Permeability from basolateral to apical side in MDCK2-MDR1 cells at 5 uM in presence of 4.3 mg/ml BSA and in presence of P-gp inhibitor LSN335984 by mass spectrometry | Canis lupus familiaris | 2 | ALA3352492 | cell-based format | Scientific Literature | |
14. | ALA3385318 | A | Permeability from basolateral to apical side in MDCK2-MDR1 cells at 5 uM in presence of 4.3 mg/ml BSA and in absence of P-gp inhibitor LSN335984 by mass spectrometry | Canis lupus familiaris | 2 | ALA3352492 | cell-based format | Scientific Literature | |
15. | ALA3385940 | A | Efflux ratio, ratio of basolateral to apical side over apical to basolateral side in MDCK2-MDR1 cells at 5 uM in presence of 4.3 mg/ml BSA and in presence of P-gp inhibitor LSN335984 by mass spectrometry | Canis lupus familiaris | 2 | ALA3352492 | cell-based format | Scientific Literature | |
16. | ALA3385941 | A | Passive permeability in MDCK2-MDR1 cells at 5 uM in presence of 4.3 mg/ml BSA and in presence of P-gp inhibitor LSN335984 by mass spectrometry | Canis lupus familiaris | 2 | ALA3352492 | cell-based format | Scientific Literature | |
17. | ALA3385942 | A | Permeability in MDCK2-MDR1 cells assessed as cell associated fraction by measuring mass fraction extracted from cell monolayer by methanol wash after 1 hr flux in apical to basolateral direction at 5 uM in presence of 4.3 mg/ml BSA and in presence of P-gp inhibitor LSN335984 by mass spectrometry | Canis lupus familiaris | 2 | ALA3352492 | cell-based format | Scientific Literature | |
18. | ALA3385943 | A | Permeability in MDCK2-MDR1 cells assessed as cell associated fraction by measuring mass fraction extracted from cell monolayer by methanol wash after 1 hr flux in apical to basolateral direction at 5 uM in presence of 4.3 mg/ml BSA and in absence of P-gp inhibitor LSN335984 by mass spectrometry | Canis lupus familiaris | 2 | ALA3352492 | cell-based format | Scientific Literature | |
19. | ALA3385944 | A | Ratio of cell associated fraction in MDCK2-MDR1 cells in presence of P-gp inhibitor LSN335984 to cell associated fraction in MDCK2-MDR1 cells in absence of P-gp inhibitor LSN335984 to | Canis lupus familiaris | 2 | ALA3352492 | cell-based format | Scientific Literature | |
20. | ALA3385945 | F | Potentiation of doxorubicin-induced cytotoxicity against mouse Colon 26 cells at 0.15 uM incubated in dark for 1 hr by sulforhodamine B assay | Mus musculus | 4 | ALA3352492 | cell-based format | Scientific Literature |