# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3385531 | B | Inhibition of human cathepsin S using benzyloxycarbonyl-L-Leucyl-L-Arginine 4-Methyl-coumaryl-7-amide substrate by FRET assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
2. | ALA3385532 | B | Inhibition of mouse cathepsin S using benzyloxycarbonyl-L-Leucyl-L-Arginine 4-Methyl-coumaryl-7-amide substrate by FRET assay | Mus musculus | 5 | single protein format | Scientific Literature | ||
3. | ALA3386074 | B | Inhibition of rat cathepsin S G137C mutant using benzyloxycarbonyl-L-Leucyl-L-Arginine 4-Methyl-coumaryl-7-amide substrate by FRET assay | Rattus norvegicus | 5 | assay format | Scientific Literature | ||
4. | ALA3386076 | P | Lipophilicity, log P of the compound | 2 | small-molecule physicochemical format | Scientific Literature | |||
5. | ALA3386077 | P | Lipophilicity, log D of the compound at pH 4.0 | 2 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA3386078 | P | Dissociation constant, basic pKa of the compound | 2 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA3386079 | A | Solubility in simulated gastric fluid | 2 | tissue-based format | Scientific Literature | |||
8. | ALA3386080 | A | Oral bioavailability in Beagle dog at 3 mg/kg | Canis lupus familiaris | 2 | organism-based format | Scientific Literature | ||
9. | ALA3386081 | A | Clearance in Beagle dog at 1 mg/kg, iv or 3 mg/kg, po | Canis lupus familiaris | 2 | organism-based format | Scientific Literature | ||
10. | ALA3386082 | A | Volume of distribution in Beagle dog at 1 mg/kg, iv or 3 mg/kg, po | Canis lupus familiaris | 2 | organism-based format | Scientific Literature | ||
11. | ALA3387376 | A | Inhibition of CYP3A4 (unknown origin) using midazolam substrate at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
12. | ALA3387377 | A | Inhibition of CYP2D6 (unknown origin) using bufuralol substrate at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
13. | ALA3387378 | A | Inhibition of CYP2C9 (unknown origin) using diclofenac substrate at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
14. | ALA3387379 | A | Drug metabolism in mouse liver microsomes after 30 mins at 4 uM | Mus musculus | 2 | assay format | Scientific Literature | ||
15. | ALA3387380 | A | Drug metabolism in rat liver microsomes after 30 mins at 4 uM | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
16. | ALA3387381 | A | Drug metabolism in dog liver microsomes after 30 mins at 4 uM | Canis lupus familiaris | 2 | assay format | Scientific Literature | ||
17. | ALA3387382 | A | Drug metabolism in human liver microsomes after 30 mins at 4 uM | Homo sapiens | 2 | assay format | Scientific Literature | ||
18. | ALA3387383 | A | Permeability from apical to basolateral side in MDCK cells at 2.5 uM incubated for 1 hr | Canis lupus familiaris | 2 | cell-based format | Scientific Literature | ||
19. | ALA3387940 | F | Inhibition of CaCl2-induced abdominal aortic aneurysm in 129SvEv mouse assessed as reduction in aortic diameter at 1 to 30 mg/kg dosed through oral gavage BID for 4 weeks with first dose given one day prior to surgery | Mus musculus | 2 | organism-based format | Scientific Literature |