# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3370438 | B | Inhibition of Plasmodium falciparum plasmepsin V assessed as cleavage of wtKAHRP fluorogenic substrate at 1 uM | Plasmodium falciparum | 44 | single protein format | Scientific Literature | ||
2. | ALA3739199 | B | Inhibition of HA-tagged transgenic Plasmodium falciparum plasmepsin 5 using DABCYL-RNKRTLAQKQ-E-EDANS as substrate after 120 mins by fluorescence plate reader analysis | Plasmodium falciparum | 7 | assay format | Scientific Literature | ||
3. | ALA3739200 | F | Antiparasitic activity against early ring-stage of Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of parasite viability after 72 hrs by flow cytometric analysis | Plasmodium falciparum | 8 | organism-based format | Scientific Literature | ||
4. | ALA3739201 | A | Cytotoxicity against human HepG2 cells after 48 hrs by CellTiter Glo assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
5. | ALA3739202 | P | Stability in phosphate buffer at 5000 ng/ml at 37 degC at pH 7.4 measured over 24 hrs by LC-MS analysis in presence of porcine pancreatin | 5 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA3739203 | A | Metabolic stability in human serum at 5000 ng/ml at 37 degC measured over 55 hrs by LC-MS analysis | Homo sapiens | 5 | assay format | Scientific Literature | ||
7. | ALA3739204 | B | Inhibition of plasmepsin 5 in trophozoite stage of transgenic Plasmodium falciparum infected in erythrocytes assessed as suppression of PEXEL processing of GFP-fused EMP3 at 20 uM after 5 hrs by Western blot analysis | Plasmodium falciparum | 7 | cell-based format | Scientific Literature |