# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3391325 | Binding | Inhibition of full length human NOX2 transfected in COS 22 cells assessed as inhibition of lithium dodecyl sulphate-stimulated ROS generation at 6.3 uM preincubated for 15 mins followed by lithium dodecyl sulphate challenge by cell-free assay in presence of NADPH | Homo sapiens | 1 | ALA3390837 | cell-based format | Scientific Literature | |
2. | ALA3391326 | Binding | Inhibition of full length human NOX2 transfected in COS 22 cells assessed as inhibition of Phorbol 12-myristate 13-acetate-stimulated ROS generation by chemiluminescence assay | Homo sapiens | 18 | ALA3390837 | cell-based format | Scientific Literature | |
3. | ALA3391327 | Binding | Inhibition of full length human NOX2 transfected in COS 22 cells assessed as inhibition of Phorbol 12-myristate 13-acetate-stimulated ROS generation by measuring H2O2 production by fluorescence assay in presence of superoxide dismutase | Homo sapiens | 18 | ALA3390837 | cell-based format | Scientific Literature | |
4. | ALA3391328 | Binding | Inhibition of full length human NOX1 transfected in COS 22 cells assessed as inhibition of Phorbol 12-myristate 13-acetate-stimulated ROS generation by chemiluminescence assay | Homo sapiens | 18 | ALA3390837 | cell-based format | Scientific Literature | |
5. | ALA3391329 | Binding | Inhibition of full length human NOX4 transfected in COS 22 cells assessed as inhibition of Phorbol 12-myristate 13-acetate-stimulated ROS generation by measuring H2O2 production by fluorescence assay in presence of superoxide dismutase | Homo sapiens | 18 | ALA3390837 | cell-based format | Scientific Literature | |
6. | ALA3391330 | Binding | Inhibition of full length human NOX5 transfected in HEK cells assessed as inhibition of ionomycin-stimulated ROS generation by chemiluminescence assay | Homo sapiens | 18 | ALA3390837 | cell-based format | Scientific Literature | |
7. | ALA3391331 | Binding | Inhibition of bovine milk xanthine oxidase assessed as hypoxanthine-stimulated ROS generation by measuring H2O2 production at 25 to 50 uM by fluorescence assay | Bos taurus | 19 | ALA3390837 | single protein format | Scientific Literature | |
8. | ALA3391332 | ADME | Cytotoxicity against african green monkey COS7 cells expressing human p22phox assessed as cell viability at 25 to 50 uM after 15 mins by luminogenic assay | Chlorocebus aethiops | 3 | ALA3390837 | cell-based format | Scientific Literature | |
9. | ALA3734234 | Binding | Inhibition of human Nox2 expressed in COS7 cells co-transfected with human p22-phox,p47phox and p67-phox assessed as inhibition of LiDS-induced superoxide generation at 6.3 uM preincubated for 15 mins followed by addition of LiDS and NADPH | Homo sapiens | 1 | ALA3727360 | cell-based format | Patent Bioactivity Data | |
10. | ALA3734235 | Binding | Inhibition of human Nox2 expressed in COS7 cells co-transfected with human p22-phox,p47phox and p67-phox assessed as inhibition of PMA-induced superoxide generation by L-012 chemiluminescence analysis | Homo sapiens | 18 | ALA3727360 | cell-based format | Patent Bioactivity Data | |
11. | ALA3734236 | Binding | Inhibition of human Nox2 expressed in COS7 cells co-transfected with human p22-phox,p47phox and p67-phox assessed as inhibition of PMA-induced H2O2 production by amplex red dye based fluorescence assay | Homo sapiens | 18 | ALA3727360 | cell-based format | Patent Bioactivity Data | |
12. | ALA3734237 | Binding | Inhibition of human Nox4 expressed in COS7 cells assessed as inhibition of PMA-induced H2O2 production by amplex red dye based fluorescence assay | Homo sapiens | 18 | ALA3727360 | cell-based format | Patent Bioactivity Data | |
13. | ALA3734238 | Binding | Inhibition of bovine xanthine-oxidase assessed as H2O2 production at 25 to 50 uM by amplex red dye based fluorescence assay | Bos taurus | 17 | ALA3727360 | single protein format | Patent Bioactivity Data | |
14. | ALA3734239 | ADME | Cytotoxicity against african green monkey COS7 cells at high concentration for 15 mins by fluorescence analysis | Chlorocebus aethiops | 3 | ALA3727360 | cell-based format | Patent Bioactivity Data | |
15. | ALA3734240 | Binding | Inhibition of human Nox1 expressed in COS7 cells co-transfected with human NOXO1/NOXA1 assessed as inhibition of PMA-induced superoxide generation by L-012 chemiluminescence analysis | Homo sapiens | 18 | ALA3727360 | cell-based format | Patent Bioactivity Data | |
16. | ALA3734241 | Binding | Inhibition of Nox5 expressed in HEK cells assessed as inhibition of PMA/ionomycin-induced superoxide generation by L-012 chemiluminescence analysis | Homo sapiens | 18 | ALA3727360 | cell-based format | Patent Bioactivity Data |