# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3382827 | B | Displacement of biotinylated tetra-acetylated histone H4 from His6-tagged BRD2 (1 to 473 aa) (unknown origin) after 1 hr by TR-FRET assay | Homo sapiens | 29 | ALA3351476 | single protein format | Scientific Literature | |
2. | ALA3382828 | B | Displacement of biotinylated tetra-acetylated histone H4 from His6-tagged BRD3 (1 to 475 aa) (unknown origin) after 1 hr by TR-FRET assay | Homo sapiens | 29 | ALA3351476 | single protein format | Scientific Literature | |
3. | ALA3382829 | B | Displacement of biotinylated tetra-acetylated histone H4 from His6-tagged BRD4 (1 to 477 aa) (unknown origin) after 1 hr by TR-FRET assay | Homo sapiens | 29 | ALA3351476 | single protein format | Scientific Literature | |
4. | ALA3382830 | A | Solubility of the compound in fasted state simulated intestinal fluid at 125 ug/ml after 16 hrs by HPLC analysis | 9 | ALA3351476 | assay format | Scientific Literature | ||
5. | ALA3382831 | F | Upregulation of ApoA1 in human HepG2 cells after 16 hrs by luciferase reporter assay relative to control | Homo sapiens | 29 | ALA3351476 | cell-based format | Scientific Literature | |
6. | ALA3382832 | F | Inhibition of LPS-induced IL6 production in human PBMC after 18 to 24 hrs by immunoassay | Homo sapiens | 2 | ALA3351476 | cell-based format | Scientific Literature | |
7. | ALA3382833 | F | Inhibition of LPS-induced IL6 production in human whole blood after 24 hrs by immunoassay | Homo sapiens | 2 | ALA3351476 | tissue-based format | Scientific Literature | |
8. | ALA3382834 | A | Clearance in human hepatocytes assessed per gram of tissue at 1 uM by LC-MS/MS analysis | Homo sapiens | 2 | ALA3351476 | cell-based format | Scientific Literature | |
9. | ALA3382835 | A | Clearance in rat hepatocytes assessed per gram of tissue at 1 uM by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA3351476 | cell-based format | Scientific Literature | |
10. | ALA3382836 | A | Clearance in dog hepatocytes assessed per gram of tissue at 1 uM by LC-MS/MS analysis | Canis lupus familiaris | 2 | ALA3351476 | cell-based format | Scientific Literature | |
11. | ALA3382837 | A | Clearance in Cynomolgus monkey hepatocytes assessed per gram of tissue at 1 uM by LC-MS/MS analysis | Macaca fascicularis | 2 | ALA3351476 | cell-based format | Scientific Literature | |
12. | ALA3382838 | A | Inhibition of CYP1A2 (unknown origin) expressed in Escherichia coli bactosomes using ethoxyresorufin as substrate after 10 mins by fluorescence assay | Homo sapiens | 2 | ALA3351476 | assay format | Scientific Literature | |
13. | ALA3382839 | A | Inhibition of CYP2C9 (unknown origin) expressed in Escherichia coli bactosomes using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 10 mins by fluorescence assay | Homo sapiens | 2 | ALA3351476 | assay format | Scientific Literature | |
14. | ALA3382840 | A | Inhibition of CYP2C19 (unknown origin) expressed in Escherichia coli bactosomes using 3-butyryl-7-methoxycoumarin as substrate after 10 mins by fluorescence assay | Homo sapiens | 2 | ALA3351476 | assay format | Scientific Literature | |
15. | ALA3382841 | A | Inhibition of recombinant human CYP2D6 expressed in Escherichia coli bactosomes using 4-methylaminomethyl-7-methoyxycoumarin as substrate after 10 mins by fluorescence assay | Homo sapiens | 2 | ALA3351476 | assay format | Scientific Literature | |
16. | ALA3382842 | A | Inhibition of human recombinant CYP3A4 expressed in Escherichia coli bactosomes using 7-benzloxyquinolone as substrate after 10 mins by fluorescence assay | Homo sapiens | 2 | ALA3351476 | assay format | Scientific Literature | |
17. | ALA3382843 | A | Inhibition of human recombinant CYP3A4 expressed in Escherichia coli bactosomes using diethoxyfluorescein as substrate after 10 mins by fluorescence assay | Homo sapiens | 2 | ALA3351476 | assay format | Scientific Literature |